Abstract
A number of 1,5-diarylimidazoles has been synthesized and evaluated for their inhibitory activities of COX-2 catalyzed PGE2 production. 1,5-Diarylimidazoles were obtained from imimes andp-toluenesulfonylmethyl cyanide (TosMIC). Imines were prepared from commercially available amines and aldehydes. Among the compounds tested, 1-(2,4-difluorophenyl)-5-(4-methylsulfonylphenyl) imidazole (2r) showed strong inhibitory activity, however, most diarylimidazoles exhibited little to low inhibitory activities against COX-2 catalyzed PGE2 production.
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Tuyen, T.N., Sin, KS., Kim, H.P. et al. Synthesis and antiinflammatory activity of 1,5-Diarylimidazoles. Arch Pharm Res 28, 1013–1018 (2005). https://doi.org/10.1007/BF02977393
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DOI: https://doi.org/10.1007/BF02977393