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Effects ofOpuntia ficus-indica var.Saboten stem on Gastric damages in rats

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  • Medicinal Chemistry & Natural Products
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Abstract

The effects of the dried stem powder ofOpuntia ficus-indica var. saboten (OF-s) were investigated on gastric lesion and ulcer models in rats. It showed significant inhibition in HCI ethanol-induced gastric lesion at the doses of 200 and 600 mg/kg p.o. and in HCI aspirin-induced gastric lesion at 600 mg/kg p.o. OF-s also showed significant inhibition in indomethacin-induced gastric lesion at the doses of 200 and 600 mg/kg, p.o. However, it did not affect both the aspirin-induced and Shay ulcers in rats. It also did not affect gastric juice secretion, acid output and pH. These data indicate that OF-s only possesses pronounced inhibitory action on gastric lesion without antiulcer activity in rats.

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Authors and Affiliations

  1. Natural Products Research Institute, Seoul National University, 110-460, Seoul, Korea

    Eun Bang Lee & Da Wei Li

  2. Pukjeju Agricultural Development and Technology Extension Center, 695-907, Jejudo, Korea

    Yung In Moon

Authors
  1. Eun Bang Lee
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  2. Jin Ee Hyun
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  3. Da Wei Li
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  4. Yung In Moon
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Correspondence to Eun Bang Lee.

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Lee, E.B., Hyun, J.E., Li, D.W. et al. Effects ofOpuntia ficus-indica var.Saboten stem on Gastric damages in rats. Arch Pharm Res 25, 67–70 (2002). https://doi.org/10.1007/BF02975264

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  • DOI: https://doi.org/10.1007/BF02975264

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