Abstract
The synthesis of phenoxyalkanoic acid derivatives and their anti-inflammatory and analgesic activities are described. Analysis of structure-activity relationships shows that in trichlorophenoxy derivatives anti-edematous potency is associated with the presence of 1-thiopropyl moiety and 2 or 4-aminopyridyl moiety at R′ position contributes to the analgesic activity.
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Shin, K.H., Lee, E.B., Park, S.W. et al. Synthesis and anti-inflammatory and analgesic activities of phenoxyalkanoic acid derivatives. Arch. Pharm. Res. 20, 72–75 (1997). https://doi.org/10.1007/BF02974045
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DOI: https://doi.org/10.1007/BF02974045