Skip to main content
Log in

Synthesis and anti-inflammatory and analgesic activities of phenoxyalkanoic acid derivatives

  • Research Articles
  • Published:
Archives of Pharmacal Research Aims and scope Submit manuscript

Abstract

The synthesis of phenoxyalkanoic acid derivatives and their anti-inflammatory and analgesic activities are described. Analysis of structure-activity relationships shows that in trichlorophenoxy derivatives anti-edematous potency is associated with the presence of 1-thiopropyl moiety and 2 or 4-aminopyridyl moiety at R′ position contributes to the analgesic activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References Cited

  • Domenjoz, R., Synthetic anti-inflammatory drugs concepts of their mode of action.Adv. Pharmac. 4, 143–217 (1966).

    Article  CAS  Google Scholar 

  • Goodman, L.S. and Gilman, A.,The pharmacological basis of therapeutics (Fifth ed.). Macmillan Pub. Co. Inc., pp. 1472–1497, 1975.

  • Hanzlik, P.J.,Actions and uses of the salicylates and cinchophen in medicine. The Williams & Wilkins Co., Baltimore (1927).

    Google Scholar 

  • Hench, P.S., Kendall, E.C., Slocumb, C.H. and Polley, H.S., The effect of a hormone of the adrenal cortex and of pituitary adrenocorticotropic hormone on rheumatoid arthritis.Proc. Staff Meet. Mayo Clin., 24, 181–197 (1949).

    CAS  Google Scholar 

  • Mizushima, Y.,Inflammation and anti-inflammatory drugs. Nankodo Ltd., pp. 118–120, 1968.

  • Takagi, H., Inukai, M. and Nakama, M., A modification of Hoffner's method for testing analgesics.Jpn. J. Pharmacol., 16, 287–294(1966).

    Article  PubMed  CAS  Google Scholar 

  • Whittle, B.A., The use of changes in capillary permeability in mice to distinguish between narcotic and non-narcotic analgesics.Br. J. Pharmacol. Chemother., 22, 246–252(1964).

    PubMed  CAS  Google Scholar 

  • Winter, C.A., Risley, E.A. and Nuss, G.W., Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs.Proc. Soc. Exp. Biol. Med., 111, 544–548(1962).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shin, K.H., Lee, E.B., Park, S.W. et al. Synthesis and anti-inflammatory and analgesic activities of phenoxyalkanoic acid derivatives. Arch. Pharm. Res. 20, 72–75 (1997). https://doi.org/10.1007/BF02974045

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02974045

Key words

Navigation