Abstract
Benzothiazole derivatives of thiazolidinediones (TZD) were synthesized using a modified Mitsunobu reaction of 2-(benzothiazol-2-ylmethylamino)ethanol (2) with 5-(4-hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione and assayed for activity on peroxisome proliferator-activated receptor (PPAR) subtypes and inhibitory activity of NO production in lipopolysaccharide-activated macrophages. Most of the tested compounds were identified as potent PPARγ agonists, indicating their potential as drug candidates for diabetes.
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Jeon, R., Kim, YJ., Cheon, Y. et al. Synthesis and biological activity of [[(heterocycloamino)alkoxy] benzyl]-2,4-thiazolidinediones as PPARγ agonists. Arch Pharm Res 29, 394–399 (2006). https://doi.org/10.1007/BF02968589
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DOI: https://doi.org/10.1007/BF02968589