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Significance of the parathyroid hormone-related protein expression in breast carcinoma

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Abstract

Background

Parathyroid hormone-related protein (PTHrP) is produced by various neoplasms and is known to be a causative factor of hypercalcemia of malignancy. It has also been suggested to act as a cytokine for tumor progression. The purpose of this study was to clarify the significance of PTHrP expression in breast carcinoma.

Methods

PTHrP expression was examined in 177 surgically resected breast carcinoma specimens by immunohistochemistry using a monoclonal antibody against the for PTHrP, The relationship of PTHrP expression with clinicopathological factors was analyzed and the clinical courses of the patients are reported.

Results

Positive PTHrP staining was detected in 113 ( 64%) of the breast tumors. Among the positive cases, 36 (32%) of the tumors clearly showed strong expression. When the PTHrP expression was divided into three categories, a significant positive relationship was found between PTHrP expression and histological grade of tumor. PTHrP expression was also significantly related to bone metastasis but the staining degree of PTHrP was not. The patients with positive PTHrP tended to have poor outcome in proportion to the staining degree. Univariate analysis demonstrated a significantly shorter overall survival for patients expressing PTHrP, and in multivariate analysis showed that PTHrP status and nodal status were associated with a significantly shorter overall survival.

Conclusion

Our results suggest that PTHrP expression is not only correlated with bone metastasis but is also related to the progression of breast carcinoma, and that overexpression of PTHrP may be a potential prognostic factor for human breast carcinoma.

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Abbreviations

PTHrP:

Parathyroid hormone-related protein

ER:

Estrogen receptor

PgR:

progesterone receptor

EGF:

Epidermal growth factor

TGB-β:

Transforming growth factor- β

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Authors and Affiliations

  1. Second Division of Surgery, Kanagawa Cancer Center, Japan

    Akira Yoshida, Atsushi Nagano, Masaaki Inaba & Taro Asaga

  2. Clinical Resarch Institute, Kanagawa Cancer Center, Japan

    Yoshiyasu Nakamura, Akio Shimizu & Masaoki Harada

  3. Department of Pathology, Kanagawa Cancer Center, Japan

    Youichi Kameda

Authors
  1. Akira Yoshida
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  2. Yoshiyasu Nakamura
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  3. Akio Shimizu
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  4. Masaoki Harada
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  5. Youichi Kameda
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  6. Atsushi Nagano
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  7. Masaaki Inaba
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  8. Taro Asaga
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Yoshida, A., Nakamura, Y., Shimizu, A. et al. Significance of the parathyroid hormone-related protein expression in breast carcinoma. Breast Cancer 7, 215–220 (2000). https://doi.org/10.1007/BF02967463

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  • DOI: https://doi.org/10.1007/BF02967463

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