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Modulation of metal toxicity by metallothionein

  • Section 2 Metal Binding Proteins and Metal Resistance
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Abstract

Toxic properties of several metals may be modified, since they are bound to metallothionein in vivo. Such modulation is particularly well known for cadmium (Cd), whose acute effects are prevented by metallothionein induction, whereas chronic effects on the kidney are partly explained on the basis of transport of cadmium-metallothionein (CdMt) into the kidney. Although intracellular Mt synthesis is induced by Cd, offering partial protection, nephrotoxicity may occur at times when such protection is insufficient. Pertubations in renal calcium metabolism may be an important basis for membrane dysfunction leading to proteinuria.

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Authors and Affiliations

  1. Department of Environmental Medicine, University of Umeå, S-901 87, Umeå, Sweden

    Gunnar F. Nordberg

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  1. Gunnar F. Nordberg
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Nordberg, G.F. Modulation of metal toxicity by metallothionein. Biol Trace Elem Res 21, 131–135 (1989). https://doi.org/10.1007/BF02917245

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  • DOI: https://doi.org/10.1007/BF02917245

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