Summary
The electrochemical behaviour of a series of copper(II) complexes of 2-acetylpyridine 3-azacyclothiosemicarbazones is reported. The complexes undergo a quasireversible one electron reduction in the range −0.400 to −0.450 Vversus Ag/AgCl, attributable to the copper(II)/-copper(I) redox couple. The electrochemical, as well as spectral characteristics of these complexes, can be correlated with their antifungal activity againstAspergillus niger, Paecilomyces variotti, Penicillum rubrum andAspergillus terreus.
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E. J. Blanz, Jr. and F. A. French,Cancer Res.,28, 2419 (1968); J. C. Logan, M. P. Fox, J. H. Morgan, A. M. Makohan and C. J. Pfau,J. Gen. Virol,28, 271 (1975); and A. S. Dobek, D.L. Klayman, E. J. Dickson, Jr., J. P. Scovill and E. C. Tremont,Antimicrob. Agents Chemotherapy,18, 27 (1980).
E. C. Moore, M. S. Zedeck, K. C. Agrawal and A. C. Sartorelli,Cancer Res.,9, 4452 (1970).
D. L. Klayman, J. E. Bartosevich, T. S. Griffin, C. J. Mason and J. P. Scovill,J. Med. Chem.,22, 855 (1979).
F. M. Collins, D. L. Klayman and N. E. Morrison,J. Gen. Microbiol.,128, 1349 (1982).
M. Hooper and M. G. Purhoit,Prog. Med. Chem.,20, 1 (1983).
L. A. Saryan, E. Ankel, C. Krishnamurti, W. E. Antholine and D. H. Petering,Biochem. Pharmacol.,30, 1595 (1981); J. P. Scovill, D. L. Klayman and C. F. Franchino,J. Med. Chem.,25, 1261 (1982).
L. A. Saryan, E. Ankel, C. Krishnamurti, D. H. Petering and H. Elford,J. Med. Chem.,22, 1218 (1979).
S. B. Padhye and G. B. Kaufmann,Coord. Chem. Rev.,63, 17 (1985).
D. X. West, S. B. Padhye and P. B. Sonawane,Structure and Bonding,76, 1 (1991).
H. K. Parwana, G. Singh and P. Talwar,Inorg. Chim. Acta,108, 87 (1985).
B. Christenson, J. R. Rodriguez, H. F. Gorbea and C. H. Ramirez Ponda,Antimicrob. Agents and Chemotherapy,27, 570 (1985).
A. S. Kumbhar, S. B. Padhye, D. X. West and A. E. Liberta,Transition. Met. Chem.,16, 271 (1991).
A. S. Kumbhar, S. B. Padhye, A. P. Saraf, H. B. Mahajan, B. A. Chopade and D. X. West,Biol Metals, in press.
D. X. West, R. M. Makeever, J. P. Scovill and D. L. Klayman,Polyhedron,3, 947 (1984).
D. X. West, C. S. Carlson, C. P. Galloway, A. E. Liberta and C. R. Daniel,Transition Met. Chem.,15, 91 (1990).
D. X. West, C. S. Carlson, K. J. Bouck and A. E. Liberta,Transition Met. Chem.,16, 271 (1991).
M. J. M. Campbell,Coord. Chem. Rev.,15, 279 (1975).
D. X. West, S. P. Padhye, S. B. Padhye, P. B. Sonawane and R. C. Chikate,Asian J. Chem. Rev.,1, 125 (1990).
V. Eisner and E. Karowa Eisner in A. J. Bard and H. Lund (Eds).Encyclopedia of Electrochemistry of Elements, Marcell Dekker, New York, (1979), Vol. 13, p. 348.
R. J. Butcher and D. X. West, manuscript in preparation.
R. S. Nicholson and I. Shain,Anal. Chem.,36, 706 (1964).
A. R. Hendrickson, R. L. Martin and N. M. Rhode,Inorg. Chem.,15, 2115 (1976).
W. E. Geiger,Prog. Inorg. Chem.,33, 275 (1985).
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Kumbhar, A.S., Padhye, S.B., West, D.X. et al. Electrochemical studies of transition metal complexes of 2-acetyl-pyridine thiosemicarbazones. Part 2. Correlations with spectral and antifungal properties of copper(II) complexes of 2-acetylpyridine 3-azacyclothiosemicarbazones. Transition Met. Chem. 17, 247–249 (1992). https://doi.org/10.1007/BF02910848
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DOI: https://doi.org/10.1007/BF02910848