Abstract
Among ten bipolar depressed patients admitted to our psychiatric ward, five patients were treated with fluoxetine alone and five subjects were treated with fluoxetine in association with total sleep deprivation (TSD) in order to evaluate the effect of the interaction between the administration of the serotonergic antidepressant compound fluoxetine and repeated cycles of TSD. Patients treated with fluoxetine plus repeated TSD showed a faster amelioration of depressive symptomatology compared with the other group. We discuss our findings hypothesizing an enhancement in dopaminergic and possibly in serotonergic transmission due to repeated TSD adding to the increase in serotonergic transmission due to fluoxetine medication.
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References
Altamura AC, Montgomery SA (1990) Fluoxetine dose, pharmacokinetics and clinical efficacy. Rev Contemp Pharmacother 1: 75–81
American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders (DSM-III-R) 3rd edn, revised. American Psychiatric Press, Washington, DC
Asikainen M, Deboer T, Porkka-Heiskanen T, Stenberg D, Tobler I (1995) Sleep deprivation increases brain serotonin turnover in the Djungarian hamster. Neurosci Lett 198:21–24
Baumgartner A, Riemann D, Berger M (1990) Neuroendocrinological investigations during sleep deprivation in depression. Biol Psychiatry 28:569–587
Baxter LR, Liston EH, Schwartz JM, Altshuler LL, Wilkins JN, Richeimer S, Guze BH (1986) Prolongation of the antidepressant response to partial sleep deprivation by lithium. Psychiatry Res 19:17–23
Benedetti F, Barbini B, Campori E, Colombo C, Smeraldi E (1996) Dopamine agonist amineptine prevents the antidepressant effect of sleep deprivation. Psychiatry Res (in press)
Berger M, Hohagen F, König A, Vollmann J, Lohner H, Faller C, Edali N, Riemann D (1995) Chronotherapeutische Ansätze bei depressiven Erkrankungen. Wien Med Wochenschr 145:418–422
Blier P, Montigny C de, Chaput Y (1987) Modification of the serotonin system by antidepressant treatments: implication for the therapeutic response in major depression. J Clin Psychopharmacol 7 (Suppl 6):24S-35S
Bouhuys AL, Van den Burg W, Van den Hoofdakker RH (1995) The relationship between tiredness prior to sleep deprivation and the antidepressant response to sleep deprivation in depression. Biol Psychiatry 37:457–461
Ebert D, Kaschka W (1995) Humorale Aspekte des Schlafentzuges. Fortschr Neurol Psychiatry 63:441–450
Ebert D, Kaschka W, Stegbauer P, Schrell U (1993) Prolactin response to sulpiride before and after sleep deprivation in depression. Biol Psychiatry 33:666–669
Ebert D, Feistel H, Kaschka W, Barocka A, Pirner A (1994) Single photon emission computerized tomography assessment of cerebral dopamine D2 receptor blockade in depression before and after sleep deprivation. Preliminary results. Biol Psychiatry 35: 880–885
Elsenga S, Van den Hoofdakker RH (1983) Clinical effects of sleep deprivation and clomipramine in endogenous depression. J Psychiatry Res 17: 361–374
Ferre S, Cortes R, Artigas F (1994) Dopaminergic regulation of the serotonergic raphestriatal pathway: microdialysis studies in freely moving rats. J Neurosci 14:4839–4846
Fratta W, Collu M, Martellotta MC, Pichiri M, Muntoni F, Gessa GL (1987) Stress-induced insomnia: opioid-dopamine interactions. Eur J Pharmacol 142:437–440
Gerner RH, Paot RM, Gillin JC (1979) Biological and behavioral effects of one night’s sleep deprivation in depressed patients and normals. Psychiatry Res 15: 21–40
Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56–62
Haug HJ (1992) Prediction of sleep deprivation outcome by diurnal variation of mood. Biol Psychiatry 31:271–278
Holsboer-Trachsler E, Hemmeter U, Hatzinger M, Seifritz E, Gerhard U, Hobi V (1994) Sleep deprivation and bright light as potential augmenters of antidepressant drug treatment: neurobiological and psychometric assessment of course. J Psychiatr Res 28:381–399
Kasper S, Sack DA, Wehr TA (1988) Nocturnal TSH and prolactin secretion during sleep deprivation and prediction of antidepressant response in patients with major depression. Biol Psychiatry 24:631–641
Kuhs H, Tolle R (1991) Sleep deprivation therapy. Biol Psychiatry 29:1129–1148
Kuhs H, Farber D, Borgstadt S, Mrosek S, Tolle R (1996) Amitriptyline in combination with repeated late sleep deprivation versus amitriptyline alone in major depression. A randomised study. J Affect Disord 37:31–41
Lauterbach EC (1994) Sleep benefits and sleep deprivation in subgroups of depressed patients with Parkinson’s disease (letter). Am J Psychiatry 151: 782–783
Leibenluft E, Wehr TA (1992) Is sleep deprivation useful in the treatment of depression? Am J Psychiatry 149: 159–168
Leibenluft E, Moul DE, Schwartz PJ, Madden PA, Wehr TA (1993) A clinical trial of sleep deprivation in combination with antidepressant medication. Psychiatry Res 46:213–227
Montgomery SA (1989) The efficacy of Fuoxetine as an antidepressant in the short and long term. Int Clin Psychopharmacol 4 (Suppl 1):113–119
Neumeister A, Goessler R, Lucht M, Kapitany T, Bamas C, Kasper S (1996) Bright light therapy stabilizes the antidepressant effect of partial sleep deprivation. Biol Psychiatry 39:1621
Riemann D, Vollmann J, Hohagen F, Lohner H, König A, Faller C, Edali N, Berger M (1995) Behandlung von Depressionen mit Schlafentzug und Schlafphasenvorverlagerung. Fortschr Neurol Psychiatr 63:270–276
Riemann D, Hohagen F, König A, Schwarz B, Gomille J, Voderholzer U, Berger M (1996) Advanced vs. normal sleep timing: effects on depressed mood after response to sleep deprivation in patients with a major depressive disorder. J Affect Disord 37:121–128
Salomon RM, Delgado PL, Licinio J, Krystal JH, Heninger GR, Charney DS (1994) Effects of sleep deprivation on serotonin function in depression. Biol Psychiatry 36:840–846
Shelton RC, Loosen PT (1993) Sleep deprivation accelerates the response to nortryptiline. Prog Neuropsychopharmacol Biol Psychiatry 17: 113–123
Szuba MP, Baxter LIZ, Fairbanks LA, Guze BH, Schwartz JM (1991) Effect of partial sleep deprivation on the diurnal variation of mood and motor activity in major depression. Biol Psychiatry 30:817–829
Szuba MP, Baxter LR, Altshuler LL, Allen EM, Guze BH, Schwartz JM, Liston EH (1994) Lithium sustains the acute antidepressant effects of sleep deprivation: preliminary findings from a controlled study. Psychiatry Res 51:283–295
Vogel GW, Vogel F, Abey RS, Thurmond AJ (1980) Improvement of depression by REM sleep deprivation. Arch Gen Psychiatry 37:247–253
Wehr T (1990) Effects of sleep and wakefulness in depression and mania. In: Montplaisir J, Godbout R (eds) Sleep and biological rhythms. Oxford University Press, London, pp 42–86
Wesemann W, Weiner N, Rotsch M, Schulz E (1983) Serotonin binding in rat brain: circadian rhythm and effect of sleep deprivation. J Neural Transm Suppl 18: 287–294
Wu JC, Bunney WE (1990) The biological basis of the antidepressant response to sleep deprivation and relapse: review and hypothesis. Am J Psychiatry 147:14–21
Zwicker A, Calil H (1986) The effects of REM sleep deprivation on striatal dopamine receptor sites. Pharmacol Biochem Behav 24:809–812
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Benedetti, F., Barbini, B., Lucca, A. et al. Sleep deprivation hastens the antidepressant action of fluoxetine. Eur Arch Psychiatry Clin Nuerosci 247, 100–103 (1997). https://doi.org/10.1007/BF02900200
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DOI: https://doi.org/10.1007/BF02900200