Abstract
Immunization with various cell-wall fractions ofM. tuberculosis H37Ra, progressively depleted of lipids (cell-wall-insoluble fraction; CWIF), soluble proteins (cell-wall core; CWC), mycolic acids and arabinogalactans (cell-wall-protein-peptidoglycan complex; CW-PPC) elicited significant levels of both humoral and cell-mediated immune response. Mice immunized with these fractions, when challenged with an LD50 dose ofM. tuberculosis H37Rv, exhibited significant protection as revealed by high survival rates and decreased bacterial load in lungs, liver and spleen, as compared to nonimmunized animals.
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Chugh, I.B., Kansal, R., Vinayak, V.K. et al. Protective efficacy of different cell-wall fractions ofMycobacterium tuberculosis . Folia Microbiol 37, 407–412 (1992). https://doi.org/10.1007/BF02899898
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DOI: https://doi.org/10.1007/BF02899898