Summary
The effect of Sinomenine on IL-8, IL-6, IL-2 and mIL-2R produced by peripheral blood mononuclear cells was investigated by using cell culture, radioimmunoassay and flow cytometry. It was showed that production of IL-8 and mIL-2R was inhibited, but the levels of IL-6 were enhanced by Sinomenine. Our results also demonstrated that Sinomenine did not have any effect on the production of IL-2. The study demonstrated that Sinomenine was able to regulate the production of cytokines. This may be one of the mechanisms by which Sinomenine works on rheumatoid arthritis.
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Shenghao, T., Yonghong, H. & Fu’er, L. Effect of sinomenine on IL-8, IL-6, IL-2 produced by peripheral blood mononuclear cells. Current Medical Science 19, 257–259 (1999). https://doi.org/10.1007/BF02886956
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DOI: https://doi.org/10.1007/BF02886956