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Enzymatic changes in liver in Calcium oxalate stone forming rats treated with sodium pentosan polysulphate

  • Original Articles
  • Urolithiasis
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Abstract

The effect of sodium pentosan polysulphate (SPP) in calcium oxalate stone forming rats was studied in relation to enzymatic changes in liver. A significant increase in liver glycollate oxidase (GAO) activity was observed in stone forming rats fed sodium glycollate. SPP treatment lowered the enzyme acitivity in both stone formers and 30 days drug treated control rats. Moderate elevation in LDH activity was seen in the calculogenic group and SPP had minimal effect. The lowering of alkaline and acid phosphatase activities in stone formers was normalised with drug administration. Increases in total, Na+, K+-and Ca2+-ATPase levels in the calculogenic rats was lowered considerably with SPP treatment. Inorganic pyrophosphatase and aminotransferases were slightly reduced in glycollate-fed rats. SPP administration further lowered the pyrophosphatase level. The decrease in liver GAO during SPP administration with a consequent reduction in kidney oxalate may prove beneficial in preventing recurrence.

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Authors and Affiliations

  1. Department of Medical Biochemistry, Dr.A.L.M. Post Graduate Institute of Basic Medical Sciences, Taramani, University of Madras, 600 113, Madras, India

    K. Subha & P. Varalakshmi

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  1. K. Subha
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  2. P. Varalakshmi
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Subha, K., Varalakshmi, P. Enzymatic changes in liver in Calcium oxalate stone forming rats treated with sodium pentosan polysulphate. Indian J Clin Biochem 7, 121–124 (1992). https://doi.org/10.1007/BF02886664

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