Skip to main content
SpringerLink
Log in

Biochemical effects of various pesticides on sprayers of grape gardens

  • Published:
Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

A total of 85 healthy male pesticide sprayers in grape garden exposed to different class of pesticides for 3 to 10 years were compared with 75 controls matched for age with respect to serum cholinesterase, serum total protein, albumin, AST, ALT, hematological parameters such as Hb, Hct, RBC and serum lipid peroxidation. Serum lipid peroxidation was estimated in the form of thiobarbituric acid reactive substances (TBARS) produced. Significant decrease was observed in serum cholinesterase, serum total proteins, albumin and hematological parameters viz. Hb, Hct and RBC. Significant increase in lipid peroxidation, AST, ALT, was observed in exposed group when compared with control. These results suggest that the long term exposure of various pesticides on sprayers of grape garden affect liver, heme biosynthesis and decrease serum cholinesterase.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Dave S. K. (1998) Occupational health services for Agriculture Workers. Indian J. Occup. Environ. Med. 2, 96.

    Google Scholar 

  2. Wolfe, H.R., Durham, W.F. and Armstrong, J.F. (1967) Exposure of workers to pesticides. Arch. Environ. Health. 14, 622–633.

    PubMed  CAS  Google Scholar 

  3. MacCollom, G.B., Currier, W.W. and Baumann, G.L. (1986) Drift comparisons between aerial and ground orchard application. J. Econ. Entomol. 79, 459–464.

    Google Scholar 

  4. World health organisation (WHO) (1992) Environmental health criteria no. 130. Endrin. Geneva, World Health Organisation.

    Google Scholar 

  5. World Health Organisation (WHO) (1993) Environmental health criteria no. 145. Methyl Parathion. Geneva, World Health Organisation.

    Google Scholar 

  6. World Health Organisation (WHO) (1994) Environmental health criteria no. 153. Carbaryl. Geneva, World Health Organisation.

    Google Scholar 

  7. Feng N. Ko, George Hsiao and Yueh H. Kuo (1997) Protection of oxidative hemolysis by demethyldiisoeugenol in normal and thalassemia red blood cells. Free Radical Biol. Med. 22, 217.

    Google Scholar 

  8. Aldridge W.N. (1971) The nature of the reaction of OP compounds and Carbamates with esterases. Bull. World Health Organisation 44, 25.

    CAS  Google Scholar 

  9. Costa, L.G. (1988) Interaction of neurotoxicants with neurotransmitters system. Toxicology 49, 359–666.

    Article  PubMed  CAS  Google Scholar 

  10. World health organisation (WHO) (1986) Environmental health criteria no. 63. Organophosphorous insecticides a general introduction, World Health Organisation, Geneva, p-181.

    Google Scholar 

  11. Avashia B.H. (1987) Is Carbaryl safe as it's reputation. Letter to the Editor Am. J. Med, 83, 1168–1169.

    CAS  Google Scholar 

  12. Kummer, R. and Van Sittert, N.J. (1986). Field studies on health effects from the application of two OP insectidide formulation by handheld ULV to cotton. Toxicol. Lett. 33, 7–24.

    Article  PubMed  CAS  Google Scholar 

  13. ECETOC (1992) Evaluation of the neurotoxic potential of chemicals, Brussels, European Centre for Ecotoxicology and toxicology of chemicals (Monograph No. 18).

    Google Scholar 

  14. ECETOC (1998) OP pesticides and long term effects on the nervous system. Brussels, European Centre for Ectoxicology and Toxicology of chemicals. (Technical Report No. 75).

    Google Scholar 

  15. Maxwell, D.M., Lenz, D.E., Croff, W.A., Kaminskis, A. and Froehlich H.L. (1987) The effects of blood flow & detoxification onin vivo cholinesterase inhibition by soman in rats. Toxicol. Appl. Pharmacol. 88, 66–76.

    Article  PubMed  CAS  Google Scholar 

  16. Padilla S., Wilson, V.Z. and Bushnell, P.J. (1994) Studies on the correlation between blood cholinesterase inhibition and tissue inhibition in pesticide treated rats. Toxicology 92, 11–25.

    Article  PubMed  CAS  Google Scholar 

  17. Meena, K., Gupta, P.K. and Bawa, S.R. (1978) Endrin—induced toxicity in normal and irradiated rats. Environ. Res. 16, 373–382.

    Article  PubMed  CAS  Google Scholar 

  18. Bushnell, P. Padilla, S., Ward, T., Pope, C. and Oiszyk, V. (1991) Behavioral and nerochemical changes in rats dose repeated with diisopropyl flurophosphate (DEP). J. Pharmacol. Exp. Ther. 256, 741–750.

    PubMed  CAS  Google Scholar 

  19. Tendon, P., Padilla, S., Pope, C.N. and Tilson, H.A. (1994) Fenthion produces a persistent decrease in muscarinic receptor function in the adult rat retina. Toxicol. Appl. Pharmacol. 125, 271–280.

    Article  Google Scholar 

  20. Ray D.E. (1999) Chronic effects of low level exposure to anticholinesterases a mechanistic review. Toxicol. Lett. 103, 527–533.

    Article  Google Scholar 

  21. Bomhard, E., Loser, E., and Schilde, B. (1981), [E5605-Methyl] (Methyl parathion) chronic toxicological studies in rats (2 year feedingtrial) Wuppartal—Elberfeld Bayer AG, Institute of toxicology IPCS-145, 155.

  22. Kagan, J. (1971) Topical questions about the toxicology of phosphorganic insecticides, Ernahrungsforschung 14, 503–514 (in German).

    Google Scholar 

  23. Schilde, B. and Bomhard, E. (1984) (E605-methyl (Methyl parathion) supplementary histopathological test further to the 2 year feeding trials on rats Addendum to report No. 9889). Wuppertal-Elberfeld, Bayer A. G. Ins. of toxicology. (unpublished report No. 12559 submitted to WHO by Bayer AG. Leverkusen Germany).

    Google Scholar 

  24. Subbotina, S.G., and Belonozhko, G.A. (1968). (The effect of Sevin on the thermoresistance and fractionary protein content of blood serum) Gig. Primen Toxicol. Pestic. Klin. Otrav. 442–444.

  25. Illahi, A., Amin, N., Hashmi, A.S., Nawaz, M. and Naeemur-Rahman (1986) Incidence of endrin residues in Cucumber and it's effect on biological system. J. Pak. Med. Asso. 36, 209–211.

    Google Scholar 

  26. Luckens, M.M., and Phelps KI (1969) Serum enzyme patterns in acute poisoning with organochlorine insecticides. J. Pharm. Sci. 58, 569–572.

    Article  PubMed  CAS  Google Scholar 

  27. Bhatnagar (1980) Effect of pesticide stress among pesticide factory workers in Delhi. Pub. HIM. 74, 380.

    Google Scholar 

  28. Desai I.G. (1986) Biological monitoring of group of green house pesticide sprayers. Toxicol. Lett. 33, 91–101.

    Article  Google Scholar 

  29. Ray (1992) Pollution and Health, Wiley Eastern Ltd., New Delhi (1992).

    Google Scholar 

  30. DaLy, I.W.A. (1983) Evaluation report for US-EPA of a two year chronic feeding study of methyl parathion in rats. East Millstone, New Jersey, Biodynamics Inc. (Unpublished report, submitted to WHO by Bayer A.G. Leverkusen, Germany.)

    Google Scholar 

  31. Freeman B.A. and Capo J.D. (1982) Biology of disease, free radicals and tissue injury. Lab. Invest. 47, 412.

    PubMed  CAS  Google Scholar 

  32. Pawar S.S. and Kachole M.S. (1978) Hepatic and renal microsomal electron transport reactions in endrin treated female guinea Pig. Bull. Environ. Contam. Toxicol. 20, 199–205.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, BLDEAS Shri B.M. Patil Medical College, Bijapur

    Jyotsna A. Patil & Arun J. Patil

  2. Department of Biochemistry, Shivaji University, 416 004, Kolhapur

    Sanjay P. Govindwar (Reader)

Authors
  1. Jyotsna A. Patil
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Arun J. Patil
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sanjay P. Govindwar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sanjay P. Govindwar.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Patil, J.A., Patil, A.J. & Govindwar, S.P. Biochemical effects of various pesticides on sprayers of grape gardens. Indian J Clin Biochem 18, 16–22 (2003). https://doi.org/10.1007/BF02867362

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02867362

Key words

Search

Navigation