Abstract
To evaluate nedocromil sodium 2% ophthalmic solution for the treatment of sea-sonal allergic conjunctivitis, 24 golfers with documented ragweed-pollen allergy instilled eyedrops twice daily for 4 days prior to golf-course intervention and 15 minutes before playing a round of golf during peak ragweed season. Ocular symptoms were scored at baseline (7 days before golfing), prior to instillation on the day of golf, and 30 minutes, and 1, 4, 8, and 12 hours after tee-off. Physician assessment was performed prior to tee-off, before tee-off on the ninth hole, and at the end of the 18th hole. Itching, burning, grittiness, tearing, redness, and light sensitivity were significantly decreased after nedocromil administration, as were erythema, edema, conjunctival hyperemia, and overall findings in the conjunctiva. Symptom severity scores fell approximately 30 minutes after instillation, with improvements persisting 8 and 12 hours after treatment. Most patients (92%) rated the treatment moderately or completely effective, and 83% were willing to continue its use. Physician assessments of effectiveness agreed with those of the patients. In this open-label study, nedocromil sodium eyedrops relieved the ocular symptoms of seasonal allergic conjunctivitis for up to 12 hours, well beyond a usual round of golf.
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Rererences
Reiss J, Abelson MB, George MA, Wedner HJ. Allergic conjunctivitis. In: Pepose JS, Holland GN, Wilhelmus KR, eds.Ocular Infection and Immunity. St. Louis, Mo: Mosby-Year Book; 1996:347–358.
Bacon AS, Ahluwalia P, Irani AM, et al. Tear and conjunctival changes during the allergen induced early-and late-phase responses.J Allergy Clin Immunol. 2000;106(5 pt 1):948–954.
Bielory L. Allergic and immunologic disorders of the eye. Part II: ocular allergy.J Allergy Clin Immunol. 2000;106:1019–1032.
Ciprandi G, Buscaglia S, Cerqueti PM, Canonica GW. Drug treatment of allergic conjunctivitis. A review of the evidence.Drugs. 1992;43:154–176.
Corin RE. Nedocromil sodium: a review of the evidence for a dual mechanism of action.Clin Exp Allergy. 2000;30:461–468.
Melamed J, Schwartz RH, Blumenthal MN, Zeitz HJ. Efficacy and safety of nedocromil sodium 2% ophthalmic solution b.i.d. in the treatment of ragweed seasonal allergic conjunctivitis.Allergy Asthma Proc. 2000;21:235–239.
Leino M, Carlson C, Jaanio E, et al. Double-blind group comparative study of 2% nedocromil sodium eye drops with placebo eye drops in the treatment of seasonal allergic conjunctivitis.Ann Allergy. 1990;64:398–402.
Stockwell A, Easty DL. Group comparative trial of 2% nedocromil sodium with placebo in the treatment of seasonal allergic conjunctivitis.Eur J Ophthalmol. 1994;4:19–23.
Moller C, Berg IM, Berg T, Kjellman M, Stromberg L. Nedocromil sodium 2% eye drops for twice daily treatment of seasonal allergic conjunctivitis: a Swedish multicentre placebo-controlled study in children allergic to birch pollen.Clin Exp Allergy. 1994;24:884–887.
Alexander M, Rosen LJ, Yang WH. Comparison of topical nedocromil sodium and oral terfenadine for the treatment of seasonal allergic conjunctivitis.Clin Ther. 1999;21:1900–1907.
Juniper EF. Rhinitis management: the patient’s perspective.Clin Exp Allergy. 1998;28(suppl 6): 34–38.
Leonardi A, Secchi AG, Briggs R, Allansmith MR. Conjunctival mast cells and the allergic late phase reaction.Ophthalmic Res. 1992;24:234–242.
Bonini S, Berruto A, Tomassini M, Carlesimo S, Bucci MG, Balsano F. Conjunctival provocation test as a model for the study of allergy and inflammation in humans.Int Arch Allergy Appl Immunol. 1989;88:144–148.
Hammann C, Kammerer R, Gerber M, Spertini F. Comparison of effects of topical levocabastine and nedocromil sodium on the early response in a conjunctival provocation test with allergen.J Allergy Clin Immunol. 1996;98(6 pt 1):1045–1050.
Bonini S, Vecchione A, Naim DM, Allansmith MR, Balsano F. Inflammatory changes in conjunc tival scrapings after allergen provocation in humans.J Allergy Clin Immunol. 1988;82(3 pt 1): 462–469.
Trocme SD, Kephart GM, Allansmith MR, Bourne WM, Gleich GJ. Conjunctival deposition of eosinophil granule major basic protein in vernal keratoconjunctivitis and contact lens-associated giant papillary conjunctivitis.Am J Ophthalmol. 1989;108:57–63.
Melamed J, Schwartz RH, Hirsch SR, Cohen SH. Evaluation of nedocromil sodium 2% ophthalmic solution for the treatment of seasonal allergic conjunctivitis.Ann Allergy. 1994;73:57–66.
Blumenthal M, Casale T, Dockhorn R, et al. Efficacy and safety of nedocromil sodium oph thalmic solution in the treatment of seasonal allergic conjunctivitis.Am J Ophthalmol. 1992; 113:56–63.
Kjellman NI, Stevens MT. Clinical experience with Tilavist: an overview of efficacy and safety.Allergy. 1995;50:14–22; discussion 34–38.
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Alexander, M., Allegro, S. & Hicks, A. Nedocromil sodium in golfers with seasonal allergic conjunctivitis. Adv Therapy 18, 195–204 (2001). https://doi.org/10.1007/BF02853165
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DOI: https://doi.org/10.1007/BF02853165