Abstract
Azidometalkojates of the general formula MX2 (M=Cu, Mn, Mg, Zn or Ni and X=5-hydroxy-2-azidomethyl-4H-pyran-4-one) were prepared and tested for antibacterial, antifungal and cytotoxic effects. The mangan and zinc derivatives are not active against any the tested microorganisms. A weak antibacterial activity was found with the copper derivative. The strongest antifungal effects were shown by the nickel derivative while the highest cytotoxic effect on HeLa cells was manifested by the zinc derivative.
Similar content being viewed by others
References
Bajpai P., Agrawal P.K., Vishwanathan L.: Kojic acid: Synthesis and properties.J. Sci. Ind. Res. 41, 185–194 (1982).
Bálint Š., Forsthoffer I., Brtko I., Dobias I.: Method of preparation of kojic acid.Czechoslov. Pat. 252 880;Chem. Abstr. 111, 624 (1989).
Brtko J., Dobias J., Nemec P.: Insecticidal 5-acetoxy-2-acetoxymethylpyr-4-one.Ger. Pat. 3 014 618 (1980).
Dobias J., Nemec P., Brtko J.: Inhibitory effect of kojic acid and its two derivatives on the development ofDrosophila melanogaster.Biológia 32, 417–421 (1977)
Dobias J., Balanová I., Nemec P.: Effect of kojic acid phenosazone onTrypanosoma crusel.Biológia 35, 203–207 (1980).
Durden J.A., Stansbury H.A., Catlette N.H.: Reaction of azidoorganic compounds with acetylenes.J. Chem. Eng. Data 9, 228 (1964).
Hozová B., Uherová R., Hudecová D.: Microbial and sensory aspects of kojic acid added to smoked meat products.Food Technol. Biotechnol. Rev. 32, 13–16 (1994).
Hudecová D., Uher M., Brtko J.: Halogen derivatives of kojic acid with antifungal effects.Biológia 47, 483–488 (1992).
Kotani T., Ichimoto I., Sakai H.:Bacteriostatic activity and mode of action mechanism of kojic acid.Nippon Nogei Kagaku Kaishi 56, 553–557 (1982).
Melník M., Uher M., Brtko I., Mrozinska D., Mrozinski J.: Copper(II) kojates and their antifungal effects.Polish J. Chem. 67, 1219–1229 (1993).
SANSEI Pharmaceutical Co.: Kojic acid.Kokai Tokkyo Koho 80 127 993 (1981).
SANSHO SEIYAKU Co.: Kojic acid as antioxidant.Japan Kokai Tokyo Koho 81 244 084 (1981).
Šima J., Chochulová B., Veverka M., Makáñová J., Hajšelová M., Bradiaková A.: Efficiency of the photoreduction of iron(III) complexes with kojic acid derivatives.Polish. J. Chem. 67, 1369–1374 (1993).
Uher M., Hudecová D., Brtko J., Šturdík E., Kováč J., Konečný V., Varkonda Š., Ujhélyiová L., Pódová M., Buchvald J.: A fungicidal agent.Czech. Pat. 259 592.Chem. Abstr. 113, 223 (1990).
Uher M., Brtko J., Rajniaková O., Kováč M., Novotná E.: Kojinsäure und ihre Derivate in kosmetischen und pharmazeutischen Produkten.Parfumerie und Kosmetik 74, 554 (1993).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hudecová, D., Jantová, S., Melník, M. et al. New azidometalkojates and their biological activity. Folia Microbiol 41, 473–476 (1996). https://doi.org/10.1007/BF02814660
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02814660