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B cell maturation and selection at the marrow-periphery interface

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Abstract

More than 95% of newly formed B cells die in the short interval spanning slgM acquisition in the bone marrow and entry into the long-lived pool, suggesting that selective events dictating B cell longevity occur at this stage. These likely include both ligandinduced deletion as well as discrete events that mediate recruitment to the long-lived recirculating pool. We are probing these events through the examination of normal B cell differentiation during this critical period: the characterization of a natural mutation that blocks late maturation, an irradiation/autoreconstitution model of marrow-derived B cell differentiation, and the identification of life span regulatory genes whose expression changes within this window.

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Authors and Affiliations

  1. Dept. of Pathol., Univ. of Pennsylvania, 36th and Hamilton Walk, 19104, Philadelphia, PA

    Michael P. Cancro, Vicky M. Lentz, Ryan G. Fields, Alex P. Sah & Mary Tomayko

  2. Fox Chase Cancer Research Center, Philadelphia, PA

    David M. Allman

  3. University of Wisconsin, Madison, WI

    Colleen E. Hayes

Authors
  1. Michael P. Cancro
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  2. David M. Allman
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  3. Colleen E. Hayes
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  4. Vicky M. Lentz
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  5. Ryan G. Fields
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  6. Alex P. Sah
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  7. Mary Tomayko
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Correspondence to Michael P. Cancro.

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Cancro, M.P., Allman, D.M., Hayes, C.E. et al. B cell maturation and selection at the marrow-periphery interface. Immunol Res 17, 3–11 (1998). https://doi.org/10.1007/BF02786425

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  • DOI: https://doi.org/10.1007/BF02786425

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