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Changes in plasma glucagon after total pancreatectomy in man

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Summary

Changes in the blood glucagon reactive to 30K antibody were followed in two patients before, during, and after total pancreatectomy. The blood glucagon level was decreased six hours after the operation, and then increased gradually unless insulin was administered. The increased non-pancreas glucagon was immediately suppressed by insulin administration. The glucagon secretion response to an arginine load was already low one week after the operation, and was absent even three weeks after the operation.

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Authors and Affiliations

  1. 2nd Department of Surgery, Kinki University School of Medicine, 380, Nishiyama, Sayama-cho, Minamikawachigun, Osaka, Japan

    Takaaki Sudo M.D.

  2. First Department of Surgery, Kyoto University School of Medicine, Sakyoku, Kyoto, Japan

    Takashi Suzuki M.D. & Takayoshi Tobe M.D.

Authors
  1. Takaaki Sudo M.D.
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  2. Takashi Suzuki M.D.
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  3. Takayoshi Tobe M.D.
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Sudo, T., Suzuki, T. & Tobe, T. Changes in plasma glucagon after total pancreatectomy in man. Gastroenterol Jpn 15, 464–468 (1980). https://doi.org/10.1007/BF02773909

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  • DOI: https://doi.org/10.1007/BF02773909

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