Abstract
The effect of the presence of hydroxyl groups at the side chains of di- and tripeptides on the radiation-initiated deamination and main-chain cleavage was examined. It was found that the presence of hydroxyl groups is favorable to peptide main-chain degradation with the formation of amino acid amides. The deamination was intensified or inhibited depending on the positions of OH groups in the molecules of test compounds. As a rule, both deamination and main-chain degradation processes in oxygenated solutions of di- and tripeptides were inhibited because of oxidation of hydroxyl-containing groups in the starting substances.
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Shadyro, O.I., Sosnovskaya, A.A. & Vrublevskaya, O.N. Deamination and degradation of hydroxyl-containing dipeptides and tripeptides in the radiolysis of their aqueous solutions. High Energy Chem 34, 290–294 (2000). https://doi.org/10.1007/BF02762680
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DOI: https://doi.org/10.1007/BF02762680