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Mechanisms of regulation of early embryogenesis

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Abstract

The mechanisms involved in the regulation of preimplantation mammalian development have been considered using the example of mouse embryos. The role of four factors affecting the program of early embryogenesis is discussed: nucleocytoplasmic interactions, “maternal” control of development, cell-to-cell interactions, and genomic imprinting. The current concepts of the spatial and temporal regulation of developmental processes have been reviewed, as well as the perspectives of some trends in the experimental embryology of mammals.

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References

  • Alexandre, H., Effet de l’inhibition spécifique de la replication de l’ADN par l’aphidicoline sur la différenciation primaire de l’oeuf de souris en preimplantation,C. R. Acad. Sci. Paris, Ser. III, 1982, vol. 294, pp. 1001–1006.

    CAS  Google Scholar 

  • Arnone, M.I. and Davidson, E.H., The Hardwiring of Development: Organization and Function of Genomic Regulatory Systems,Development, 1997, vol. 124, pp. 1851–1864.

    PubMed  CAS  Google Scholar 

  • Babinet, C., Richoux, V., Guenet, J.-L., and Renard, J.-P., The DDK Inbred Strain as a Model for the Study of Interactions between Parental Genomes and Egg Cytoplasm in Mouse Preimplantation Development,Development, 1990, suppl. pp. 81–87.

    Google Scholar 

  • Barlow, D.P., Methylation and Impringing: from Host Defence to Gene Regulation?,Science, 1993, vol. 260, pp. 309–310.

    Article  PubMed  CAS  Google Scholar 

  • Barton, S.C., Surani, M.A.H., and Norris, M.L., Role of Paternal and Maternal Genomes in Mouse Development,Nature, 1984, vol. 311, pp. 374–376.

    Article  PubMed  CAS  Google Scholar 

  • Bellier, S., Chastant, S., Adenot, P.,et al., Nuclear Translocation and Carboxyl-Terminal Domain Phosphorylation of RNA Polymerase II Delineate the Two Phases of Zygotic Gene Activation in Mammalian Embryos,EMBO J., 1997, vol. 16, pp. 6250–6262.

    Article  PubMed  CAS  Google Scholar 

  • Bolton, V.N., Oades, P.J., and Johnson, M.H., The Relationship between Cleavage, DNA Replication, and Activation of Transcription in the Mouse 2-Cell Embryo,J. Embryol. Exp. Morphol., 1984, vol. 79, pp. 139–163.

    PubMed  CAS  Google Scholar 

  • Braude, P.R., Time-Dependent Effects of Amanitin on Blastocyst Formation in the Mouse,J. Embryol. Exp. Morphol., 1979, vol. 52, pp. 193–202.

    PubMed  CAS  Google Scholar 

  • Calarco, P.G., Polarization of Mitochondria in the Unfertilized Mouse Oocyte,Dev. Genet., 1995, vol. 16, pp. 36–43.

    Article  PubMed  CAS  Google Scholar 

  • Campbell, K.H.S., McWhir, J., Ritchie, W.A., and Wilmut, I., Sheep Cloned by Nuclear Transfer from a Cultured Cell Line,Nature, 1996, vol. 380, pp. 64–66.

    Article  PubMed  CAS  Google Scholar 

  • Chandra, H.S. and Nanjundiah, V., The Evolution of Genomic Imprinting,Development, 1990, suppl., pp. 47–53.

    Google Scholar 

  • Chia, C.M., Winston, R.M., and Handyside, A.H., EGF, TGF, and EGFR Expression in Human Preimplantation Embryos,Development, 1995, vol. 121, pp. 299–307.

    PubMed  CAS  Google Scholar 

  • Chisholm, J.C., Johnson, M.H., Warren, P.D.,et al., Developmental Variability within and between Mouse Expanding Blastocysts and Their ICMs,J. Embryol. Exp. Morphol., 1985, vol. 86, pp. 311–336.

    PubMed  CAS  Google Scholar 

  • Christians, E., Campion, E., Thompson, E.M., and Renard, J.-P., Expression of HSP70.1 Gene, a Landmark of Early Zygotic Activity in the Mouse Embryo, Is Restricted to the First Burst of Transcription,Development, 1995, vol. 121, pp. 113–122.

    PubMed  CAS  Google Scholar 

  • Clegg, K.B and Piko, L., Quantitative Aspects of RNA Synthesis and Polyadenylation in 1-Cell and 2-Cell Mouse Embryos,J. Embryol. Exp. Morphol., 1983, vol. 74, pp. 169–182.

    PubMed  CAS  Google Scholar 

  • Collins, J.E., Lorimer, J.E., Garrod, D.R.,et al., Regulation of Desmocollin Transcription in Mouse Preimplantation Embryos.Development, 1995, vol. 121, pp. 743–752.

    PubMed  CAS  Google Scholar 

  • Conover, J.C., Temeles, G.L., Zimmermann, J.W.,et al., Stage-Specific Expression of a Family of Proteins That Are Major Products of Zygotic Gene Activation in the Mouse Embryo,Dev. Biol., 1991, vol. 144, pp. 392–404.

    Article  PubMed  CAS  Google Scholar 

  • Cran, D.G. and Esper, C.R., Cortical Granules and Cortical Reaction in Mammals,J. Reprod. Fertil., 1990, vol. 42, suppl., pp. 177–188.

    CAS  Google Scholar 

  • Curtis, D., Lehmann, R., and Zamore, P.D., Translational Regulation in Development,Cell, 1995, vol. 81, pp. 171–178.

    Article  PubMed  CAS  Google Scholar 

  • Dardik, A. and Schultz, R.M., Blastocoel Expansion in the Preimplantation Mouse Embryo—Stimulatory Effect of TGF and EGF,Development, 1991, vol. 113, pp. 919–930.

    PubMed  CAS  Google Scholar 

  • Davidson, E.H., How Embryos Work: A Comparative View of Diverse Models of Cell Fate Specification,Development, 1990, vol. 108, pp. 365–389.

    PubMed  CAS  Google Scholar 

  • Davidson, E.H., Spatial Mechanisms of Gene Regulation in Metazoan Embryos,Development, 1991, vol. 113, pp. 1–26.

    PubMed  CAS  Google Scholar 

  • Davies, T.C., Barr, K.J., Jones, D.H.,et al., Multiple Members of the Connexin Gene Family Participate in Preimplantation Development of the Mouse,Dev. Genet., 1996, vol. 18, pp. 234–243.

    Article  PubMed  CAS  Google Scholar 

  • De Sousa, P.A., Juneija, S.C., Caveney, S.,et al., Normal Development of Preimplantation Mouse Embryos Deficient in Gap Junctional Coupling,J. Cell Sci., 1997, vol. 110, pp. 1751–1758.

    PubMed  Google Scholar 

  • Dean, W.L. and Rossant, J., Effect of Delaying DNA Replication on Blastocyst Formation in the Mouse,Differentiation, 1984, vol. 26, pp. 134–137.

    Article  PubMed  CAS  Google Scholar 

  • Dyban, A.P.,Rannee razvitie mlekopitayushchikh (Early Development of Mammals), Leningrad: Nauka, 1988.

    Google Scholar 

  • Dyban, A.P. and Baranov, V.S.,Tsitogenetika razvitiya mlekopitayushchikh (Cytogenetics of Mammalian Development), Moscow: Nauka, 1978.

    Google Scholar 

  • Eager, D.D., Johnson, M.H., and Thurley, K.W., Ultrastructural Studies on the Surface Membrane of the Mouse Egg,J. Cell Sci., 1976, vol. 22, pp. 345–353.

    PubMed  CAS  Google Scholar 

  • Evsikov, A.V., Regulatory Mechanisms of Preimplantation Morphogenesis in Mice,Biopolim. Kletka, 1997, vol. 13, no. 2, pp. 93–99.

    Google Scholar 

  • Evsikov, A.V. and Solomko, A.P., Levels and Pattern of Trasnlation in Preimplantation Murine Embryos with Suppressed Cytokinese,Ontogenez, 1999, vol. 30, no. 2, pp. 103–110.

    PubMed  CAS  Google Scholar 

  • Evsikov, S.V., Embryo Viability and the Timing of Blastocoel Formation Depend on the Nucleocytoplasmic Ratio of the Reconstructed Mouse Embryos,Proc. Congress of the European Developmental Biology Organisation, 1995, Toulouse, France, p. 127.

  • Evsikov, S.V., Morozova, L.M., and Solomko, A.P., The Role of the Nucleocytoplasmic Ratio in Development Regulation of the Early Mouse Embryo,Development, 1990, vol. 109, pp. 323–328.

    PubMed  CAS  Google Scholar 

  • Evsikov, S.V., Morozova, L.M., and Solomko, A.P., Role of Ooplasmic Segregation in Mammalian Development,Roux’s Arch. Dev. Biol., 1994, vol. 203, pp. 199–204.

    Article  Google Scholar 

  • Eyal-Giladi, H., Establishment of the Axis in Chordates: Facts and Speculations,Development, 1997, vol. 124, pp. 2285–2296.

    PubMed  CAS  Google Scholar 

  • Feil, R., Walter, J., Allen, N.D., and Reik, W., Developmental Control of Allelic Methylation in the Imprinted MouseIgf2 andH19 Genes,Development, 1994, vol. 120, pp. 2933–2943.

    PubMed  CAS  Google Scholar 

  • Fraser, C.M., Gocayne, J.D., White, O.,et al., The Minimal Gene Complement ofMycoplasma genitalium, Science, 1995, vol. 270, pp. 397–403.

    Article  PubMed  CAS  Google Scholar 

  • Garbutt, C.L., Johnson, M.H., and George, M.A., When and How Does Cell Division Order Influence Cell Allocation to the Inner Cell Mass of the Mouse Blastocyst?,Development, 1987, vol. 100, pp. 325–332.

    PubMed  CAS  Google Scholar 

  • Gilbert, J., Opitz, D.M., and Ruff, R.A., A New Synthesis of Evolutionary Biology and Developmental Biology,Ontogenez, 1997, vol. 28, no. 5, pp. 325–343.

    Google Scholar 

  • Goldbard, S.B. and Warner, C.M., Genes Affect the Timing of Early Mouse Embryo Development,Biol. Reprod., 1982, vol. 27, pp. 419–424.

    Article  PubMed  CAS  Google Scholar 

  • Green, P.B., Inheritance of Pattern: Analysis from Phenotype to Gene.Am. Zool., 1987, vol. 27, pp. 657–673.

    Google Scholar 

  • Gueth-Hallonet, C. and Maro, B., Cell Polarity and Cell Diversification during Early Mouse Embryogenesis,Trends Genet., 1992, vol. 8, pp. 274–279.

    Article  PubMed  CAS  Google Scholar 

  • Haegel, H., Larue, L., Ohsugi, M.,et al., Lack of Catenin Affects Mouse Development at Gastrulation,Development, 1995, vol. 121, pp. 3529–3537.

    PubMed  CAS  Google Scholar 

  • Haig, D., Altercation of Generations: Genetic Conflicts of Pregnancy,Am. J. Reprod. Immunol., 1996a, vol. 35, pp. 226–232.

    PubMed  CAS  Google Scholar 

  • Haig, D., Gestational Drive and the Green-Bearded Placenta,Proc. Natl. Acad. Sci. USA, 1996b, vol. 93, pp. 6547–6551.

    Article  PubMed  CAS  Google Scholar 

  • Haig, D., Mother’s Boy or Daddy’s Girl?: Sex Determination in Hymenoptera,Trends Ecol. Evol., 1998, vol. 13, pp. 380–381.

    Article  Google Scholar 

  • Haig, D.M. and Westerby, M., Parent-Specific Gene Expression and the Triploid Endosperm,Am. Nat., 1989, vol. 134, pp. 147–155.

    Article  Google Scholar 

  • Heard, E., Clerc, P., and Avner, P., X-Chromosome Inactivation in Mammals,Annu. Rev. Genet., 1997, vol. 31, pp. 571–610.

    Article  PubMed  CAS  Google Scholar 

  • Henery, C.C., Miranda, M., Wiekowski, M.,et al., Repression of Gene Expression at the Beginning of Mouse Development,Dev. Biol., 1995, vol. 169, pp. 448–460.

    Article  PubMed  CAS  Google Scholar 

  • Hogan, B., Constantini, F., and Lacy, E.,Manipulating the Mouse Embryo: A Laboratory Manual, New York: Cold Spring Harbor Lab., 1986.

    Google Scholar 

  • Holliday, R., Genomic Imprinting and Allelic Exclusion,Development, 1990a, suppl., pp. 125–129.

    Google Scholar 

  • Holliday, R., Mechanisms for the Control of Gene Activity during Development,Biol. Rev., 1990b, vol. 65, pp. 431–471.

    PubMed  CAS  Google Scholar 

  • Howlett, S.K., The Effect of Inhibiting DNA Replication in the One-Cell Mouse Embryo,Roux’s Arch. Dev. Biol., 1986, vol. 195, pp. 499–505.

    Article  CAS  Google Scholar 

  • Howlett, S.K. and Bolton, V.N., Sequence and Regulation of Morphological and Molecular Events during the First Cell Cycle of Mouse Embryogenesis,J Embryol. Exp. Morphol., 1985, vol. 87, pp. 175–206.

    PubMed  CAS  Google Scholar 

  • Isaev, D.A., Platonov, E.S., and Konyukhov, B.V., Distribution of Parthenogenetic Clones of Epidermal Melanopblasts in Chimeric Mice C57BL/6(PG) ↔ (BALB/c,Ontogenez, 1999, vol. 30, no. 1, pp. 306–313.

    Google Scholar 

  • Isaev, D.A., Mironova, O.V., Platonov, E.S., and Konyukhov, B.V., Analysis of Parthenogenetic Clones in Chimeric Mice C57BL/6(PG) ↔ BALB/c,Ontogenez, 1999, vol. 30, no. 1, pp. 64–70.

    PubMed  CAS  Google Scholar 

  • Johnson, M.H., Eager, D., Muggleton-Harris, A., and Grave, H., Mosaicism in Organization of Concanavalin A Receptors on Surface Membrane of Mouse Eggs,Nature, 1975, vol. 257, pp. 321–322.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, M.H. and Ziomek, C.A., Cell Interactions Influence the Fate of Mouse Blastomeres Undergoing the Transition from the 16- to the 32-Cell Stage,Dev. Biol., 1983, vol. 95, pp. 211–218.

    Article  PubMed  CAS  Google Scholar 

  • Jones, D.H., Davies, T.C., and Kidder, G.M., Embryonic Expression of the Putative Subunit of the Sodium Pump Is Required for Acquisition of Fluid Transport Capacity during Mouse Blastocyst Development,J. Cell Biol., 1997, vol. 139, pp. 1545–1552.

    Article  PubMed  CAS  Google Scholar 

  • Jongen, W.M., Fitzgerald, D.J., Asamoto, M.,et al., Regulation of Connexin 43-Mediated Gap Junctional Intercellular Communication by Ca2+ in Mouse Epidermal Cells Is Controlled by E-Cadherin,J. Cell Biol., 1991, vol. 114, pp. 545–555.

    Article  PubMed  CAS  Google Scholar 

  • Kelly, S.J., Mulnard, J.G., and Graham, C.F., Cell Division and Cell Allocation in Early Mouse Development,J. Embryol. Exp. Morphol., 1978, vol. 48, pp. 37–51.

    PubMed  CAS  Google Scholar 

  • Kidder, G.M., The Genetic Program for Preimplantation Development,Dev. Genet., 1992, vol. 13, pp. 319–325.

    Article  PubMed  CAS  Google Scholar 

  • Kidder, G.M. and McLachlin, J.R., Timing of Transcription and Protein Synthesis Underlying Morphogenesis in Preimplantation Mouse Embryos,Dev. Biol., 1985, vol. 112, pp. 265–275.

    Article  PubMed  CAS  Google Scholar 

  • Larue, L., Ohsugi, M., Hirchenhain, J., and Kemler, R., E-Cadherin Null Mutant Embryos Fail to Form a Trophectoderm Epithelium,Proc. Natl. Acad. Sci. USA, 1994, vol. 91, pp. 8263–8267.

    Article  PubMed  CAS  Google Scholar 

  • Latham, K.E., Strain-Specific Differences in Mouse Oocytes and Their Contributions to Epigenetic Inheritance,Development, 1994, vol. 120, pp. 3419–3426.

    PubMed  CAS  Google Scholar 

  • Latham, K.E., Solter, D., and Schultz, R.M., Acauisition of a Transcriptionally Permissive State during the 1-Cell Stage of Mouse Embryogenesis,Dev. Biol., 1992, vol. 149, pp. 457–462.

    Article  PubMed  CAS  Google Scholar 

  • Latham, K.E., Garrels, J.I., and Solter, D., Alterations in Protein Synthesis Following Transplantation of Mouse 8-Cell Stage Nuclei to Enucleated 1-Cell Embryos,IBID, 1994a, vol. 163, pp. 341–350.

    CAS  Google Scholar 

  • Latham, K.E., Doherty, A.S., Scott, C.D., and Schultz, R.M.,Igf2r andIgf2 Gene Expression in Androgenetic, Gynogenetic, and Parthenogenetic Preimplantation Mouse Embryos: Absence of Regulation by Genomic Imprinting,Genes Dev., 1994b, vol. 8, pp. 290–299.

    Article  PubMed  CAS  Google Scholar 

  • Latham, K.E., Rambhatia, L., Hayashizaki, Y., and Chapman, V.M., Stage-Specific Induction and Regulation by Genomic Imprinting of the MouseU2afbp-rs Gene during Preimplantation Development,Dev. Biol., 1995, vol. 168, pp. 670–676.

    Article  PubMed  CAS  Google Scholar 

  • Lau, M.M.H., Stewart, C.E.H., Liu, Z.,et al., Loss of the Imprinted IGF2/Cation-Independent Mannose 6-Phosphate Receptor Results in Fetal Overgrowth and Perinatal Lethality,Genes Dev., 1994, vol. 8, pp. 2953–2963.

    Article  PubMed  CAS  Google Scholar 

  • Leonhardt, H., Page, A.W., Weier, H.-U., and Bestor, T.H., A Targeting Sequence Directs DNA Methyltransferase to Sites of DNA Replication in Mammalian Nuclei,Cell, 1992, vol. 71, pp. 865–873.

    Article  PubMed  CAS  Google Scholar 

  • Levy, J.B., Johnson, M.H., Goodall, H., and Maro, B., The Timing of Compaction: Control of a Major Developmental Transition in Mouse Early Embryogenesis,J. Embryol. Exp. Morphol., 1986, vol. 95, pp. 213–237.

    PubMed  CAS  Google Scholar 

  • Longo, F.J., Actin-Plasma Membrane Associations in Mouse Egggs and Oocytes,J. Exp. Zool., 1987, vol. 243, pp. 299–309.

    Article  PubMed  CAS  Google Scholar 

  • Longo, F.J. and Chen, D.-Y., Development of Cortical Polarity in Mouse Eggs: Involvement of the Meiotic Apparatus,Dev. Biol., 1985, vol. 107, pp. 382–394.

    Article  PubMed  CAS  Google Scholar 

  • Looijenga, L.H.J., Verkert, J.M.H., De Groot, N.,et al., H19 in Normal Development and Neoplasia,Mol. Reprod. Dev., 1997, vol. 46, pp. 419–439.

    Article  PubMed  CAS  Google Scholar 

  • MacPhee, D.J., Barr, K.J., DeSousa, P.A.,et al., Regulation of Na+,K+-ATPase (Subunit Gene Expression during Mouse Preimplantatin Development),Dev. Biol., 1994, vol. 162, pp. 259–266.

    Article  PubMed  CAS  Google Scholar 

  • Manejwala, F.M., Logan, C.Y., and Schultz, R.M., Regulation of hsp70 mRNA Levels during Oocyte Maturation and Zygotic Gene Activation in the Mouse,Dev. Biol., 1991, vol. 144, pp. 301–308.

    Article  PubMed  CAS  Google Scholar 

  • Mann, M., Latham, K.E., and Varmuza, S., Identification of Genes Showing Altered Expression in Preimplantation and Early Postimplantation Parthenogenetic Embryos,Dev. Genet., 1995, vol. 17, pp. 223–232.

    Article  PubMed  CAS  Google Scholar 

  • Maro, B., Johnson, M.H., Webb, M., and Flash, G., Mechanism of Polar Body Formation in the Mouse Oocyte: An Interaction between the Chromosomes, the Cytoskeleton and the Plasma Membrane,J. Embryol. Exp. Morphol., 1986, vol. 92, pp. 11–32.

    PubMed  CAS  Google Scholar 

  • Martinez-Salas, E., Cupo, D.Y., and DePamphilis, M.L., The Need for Enhancers Is Acquired upon Formation of a Diploid Nucleus during Early Mouse Development,Genes Dev., 1988, vol. 2, pp. 1115–1126.

    Article  PubMed  CAS  Google Scholar 

  • Martinez-Salas, E., Linney, E., Jassell, J., and DePamphilis, M.L., The Need for Enhancers in Gene Expression First Appears during Mouse Development with the Formation of a Zygotic Nucleus,Genes Dev., 1989, vol. 3, pp. 1493–1506.

    Article  PubMed  CAS  Google Scholar 

  • Matsumoto, K., Anzai, M., Nakagata, N.,et al., Onset of Paternal Gene Activation in Early Mouse Embryos Fertilized with Transgenic Sperm,Mol. Reprod. Dev., 1994, vol. 39, pp. 136–140.

    Article  PubMed  CAS  Google Scholar 

  • Maynard Smith, J., Models of a Dual Inheritance System,J. Theor. Biol., 1990, vol. 143, pp. 51–53.

    Article  Google Scholar 

  • McGrath, J. and Solter, D., Nuclear Transplantation in the Mouse Embryo by Microsurgery and Cell Fusion,Science, 1983, vol. 220, pp. 1300–1302.

    Article  PubMed  CAS  Google Scholar 

  • McGrath, J. and Solter, D., Nucleocytolasmic Interactions in the Mouse Embryo,J. Embryol. Exp. Morphol., 1986, vol. 97, suppl., pp. 277–289.

    PubMed  Google Scholar 

  • McLachlin, J.R. and Kidder, G.M., Intercellular Junctional Coupling in Preimplantation Mouse Embryos: Effect of Blocking Transcription or Translation,Devel. Biol., 1986, vol. 117, pp. 146–155.

    Article  CAS  Google Scholar 

  • Moore, T. and Haig, D., Genomic Imprinting in Mammalian Development: A Parental Tug-of-War,Trends Genet., 1991, vol. 7, pp. 45–49.

    PubMed  CAS  Google Scholar 

  • Nagy, A., Paldi, A., Dezso, L.,et al., Prenatal Fate of Parthenogenetic Cells in Mouse Aggregation Chimeras,Development, 1987, vol. 101, pp. 67–71.

    PubMed  CAS  Google Scholar 

  • Nagy, A., Rossant, J., Nagy, R.,et al., Derivation of Completely Cell Culture-Derived Mice from Early-Passage Embryonic Stem Cells,Proc. Natl. Acad. Sci. USA, 1993, vol. 90, pp. 8424–8428.

    Article  PubMed  CAS  Google Scholar 

  • Nicosia, S.V., Wolf, D.P., and Inoue, M., Cortical Granule Distribution and Cell Surface Characteristics in Mouse Eggs,Dev. Biol., 1977, vol. 57, pp. 56–74.

    Article  PubMed  CAS  Google Scholar 

  • Nicosia, S.V., Wolf, D.P., and Mastroianni, L., Surface Topography of Mouse Eggs before and after Insemination,Gamete Res., 1978, vol. 1, pp. 145–155.

    Article  Google Scholar 

  • Patterton, D. and Wolffe, A.P., Developmental Roles for Chromatin and Chromosomal Structure,Dev. Biol., 1996, vol. 173, pp. 2–13.

    Article  PubMed  CAS  Google Scholar 

  • Pedersen, R.A., Wu, K., and Bałakier, H., Origin of the Inner Cell Mass in Mouse Embryos: Cell Lineage Analysis by Microinjection,Dev. Biol., 1986, vol. 117, pp. 581–595.

    Article  PubMed  CAS  Google Scholar 

  • Pearsall, R.S., Shibata, H., Brozowska, A.,et al., Absence of Imprinting in U2AFBPL, a Human Homologue of the Imprinted Mouse GeneU2afbp-rs, Biochem. Biophys. Res. Commun., 1996, vol. 222, pp. 171–177.

    Article  PubMed  CAS  Google Scholar 

  • Petzoldt, U., Hoppe, P.C., and Illmensee, K., Protein Synthesis in Enucleated Fertilized and Unfertilized Mouse Eggs,Roux’s Arch. Dev. Biol., 1980, vol. 189, pp. 215–219.

    Google Scholar 

  • Petzoldt, U., Burki, K., Illmensee, G.R., and Illmensee, K., Protein Synthesis in Mouse Embryos with Experimentally Produced Asynchrony between Chromosome Replication and Cell Division,Roux’s Arch. Dev. Biol., 1983, vol. 192, pp. 138–144.

    CAS  Google Scholar 

  • Pfeifer, K., Leighton, P.A., and Tilghman, S.M., The StructuralH19 Gene Is Required for Transgene Imprinting,Proc. Natl. Acad. Sci. USA, 1996, vol. 93, pp. 13876–13883.

    Article  PubMed  CAS  Google Scholar 

  • Poueymirou, W.T. and Schultz, R.M., Regulation of the Mouse Preimplantation Development: Inhibition of Synthesis of Proteins in the Two-Cell Embryo That Require Transcription by Inhibitors of cAMP-Dependent Protein Kinase,Dev. Biol., 1989, vol. 133, pp. 588–599.

    Article  PubMed  CAS  Google Scholar 

  • Prather, R.S. and First, N.L., Reprogramming of Murine Blastocoele Formation,J. Exp. Zool., 1986, vol 237, pp. 347–350.

    Article  PubMed  CAS  Google Scholar 

  • Prather, R.S. and First, N.L., Developmental Fate in Chimeras Derived from Highly Asynchronous Murine Blastomeres,J. Exp. Zool., 1987, vol. 242, pp. 27–33.

    Article  PubMed  CAS  Google Scholar 

  • Prather, R.S. and First, N.L., Chimerization of Highly Asynchronous Murine Blastomeres: Developmental Alteration?,Gamete Res., 1988, vol. 19, pp. 359–367.

    Article  PubMed  CAS  Google Scholar 

  • Razin, A. and Riggs, A.D., DNA Methylation and Gene Function,Science, 1980, vol. 40, pp. 604–610.

    Article  Google Scholar 

  • Ram, P.T. and Schultz, R.M., Reporter Gene Expression in G2 of the 1-Cell Mouse Embryo,Dev. Biol., 1993, vol. 156, pp. 552–556.

    Article  PubMed  CAS  Google Scholar 

  • Rambhatla, L. and Latham, K.E., Strain-Specific Progression of Amanitin-Treated Mouse Embryos beyond the Two-Cell Stage,Mol. Reprod. Dev., 1995, vol. 41, pp. 16–19.

    Article  PubMed  CAS  Google Scholar 

  • Renard, J.-P., Baldacci, P., Richoux-Duranthon, V.,et al., A Maternal Factor Affecting Mouse Blastocyst Formation,Development, 1994, vol. 120, pp. 797–802.

    PubMed  CAS  Google Scholar 

  • Reithmacher, D., Brinkmann, V., and Birchmeier, C., A Targeted Mutation in the Mouse E-Cadherin Gene Results in Defective Preimplantation Development,Proc. Natl. Acad. Sci. USA, 1995, vol. 92, pp. 855–859.

    Article  Google Scholar 

  • Sawada, H., Hoshi, M., Someno, T.,et al., Inhibition of Mouse Blastocyst Hatching by Subsite-Specific Trypsin Inhibitors, Peptydyl Argininals,Dev. Growth Differ., 1992, vol. 34, pp. 357–362.

    Article  CAS  Google Scholar 

  • Schmalhausen, I.I.,Organizm kak tseloe v individual’nom i istoricheskom razviti (The Organism as a Whole In Ontogenesis and Phylogenesis), Moscow: Akad. Nauk SSSR, 1938.

    Google Scholar 

  • Schultz, R.M., Regulation of Zygotic Gene Activation in the Mouse,BioEssays, 1993, vol. 15, pp. 531–538.

    Article  PubMed  CAS  Google Scholar 

  • Sekirina, G.G. and Neganova, I.E., The Microenvironment Created by Non-Blocking Embryos in Aggregates May Rescue Blocking Embryos via Cell-Embryo Adherent Contacts,Zygote, 1995, vol. 4, pp. 313–324.

    Google Scholar 

  • Sekirina, G.G. and Neganova, I.E., Overcoming of “Two-Cell Block” of Murine Embryos in Aggregation Chimaeras,Ontogenez, 1996, vol. 27, no. 5, pp. 361–370.

    PubMed  CAS  Google Scholar 

  • Severtsov, A.N.,Etyudy po teorii evolyutsii. Individual’noe razvitie i evolyutsiya Essays on Theory of Evolution. Development and Evolution, Berlin: Gos. Izd. RSFSR, 1921.

    Google Scholar 

  • Shire, J.G.M. and Whitten, W.K., Genetic Variation in the Timing of First Cleavage in Mice: Effect of Maternal Genotype,Biol. Reprod., 1980a, vol. 23, pp. 363–368.

    Article  PubMed  CAS  Google Scholar 

  • Shire, J.G.M. and Whitten, W.K. Genetic Variation in the Timing of First Cleavage in Mice: Effect of Maternal Genotype,Biol. Reprod., 1980b, vol. 23, pp. 369–376.

    Article  PubMed  CAS  Google Scholar 

  • Smith, R. and McLaren, A., Factors Affecting the Time of Formation of the Mouse Blastocoel,J. Embryol. Exp. Morphol., 1977, vol. 41, pp. 79–92.

    PubMed  CAS  Google Scholar 

  • Solter, D., Differential Imprinting and Expression of Maternal and Paternal Genomes.Annu. Rev. Genet., 1988, vol. 22, pp. 127–146.

    Article  PubMed  CAS  Google Scholar 

  • Spindle, A., Cell Allocation in Preimplantation Mouse Chimeras,J. Exp. Zool., 1982, vol. 219, pp. 361–367.

    Article  PubMed  CAS  Google Scholar 

  • Spindle, A., Sturm, K.S., Flannery, M.,et al., Defective Chorioallantoic Fusion in Mid-Gestation Lethality of Parthenogenone ↔ Tetraploid Chimeras,Dev. Biol., 1996, vol. 173, pp. 447–458.

    Article  PubMed  CAS  Google Scholar 

  • Surani, M.A. and Barton, S.C., Development of Gynogenetic Eggs in the Mouse: Implications for Parthenogenetic Embryos,Science, 1983, vol. 222, pp. 1034–1036.

    Article  PubMed  CAS  Google Scholar 

  • Surani, M.A.H., Barton, S.C., and Burling, A., Differentiation of 2-Cell and 8-Cell Mouse Embryos Arrested by Cytoskeletal Inhibitors,Exp. Cell Res., 1980, vol. 125, pp. 275–286.

    Article  PubMed  CAS  Google Scholar 

  • Surani, M.A.H., Barton, S.C., and Norris, M.L., Development of Mouse Eggs Suggests Imprinting of the Genome During Gametogenesis,Nature, 1984, vol. 308, pp. 548–550.

    Article  PubMed  CAS  Google Scholar 

  • Surani, M.A.H., Barton, S.C., and Norris, M.L., Influence of Parental Chromosomes on Spatial Specificity in Androgenetic ↔Parthenogenetic Chimaeras in the Mouse,Nature, 1987, vol. 326, pp. 395–398.

    Article  PubMed  CAS  Google Scholar 

  • Surani, M.A., Barton, S.C., Howlett, S.K., and Norris, M.L., Influence of Chromosomal Determinants on Development of Androgenetic and Parthenogenetic Cells,Development, 1988, vol. 103, pp. 171–178.

    PubMed  CAS  Google Scholar 

  • Szabo, P. and Mann, J.R., Expression and Methylation of Imprinted Genes duringin vitro Differentiation of Mouse Parthenogenetic and Androgenetic Embryonic Stem Cell Lines,Development, 1994, vol. 120, pp. 1651–1660.

    PubMed  CAS  Google Scholar 

  • Tarkowski, A. and Wroblewska, J., Development of Blastomeres of Mouse Eggs Isolated at the 4- and 8-Cell Stage,J. Embryol. Exp. Morphol., 1967, vol. 18, pp. 155–180.

    PubMed  CAS  Google Scholar 

  • Thibault, C., Szöllösi, D., and Gerard, M., Mammalian Oocyte Maturation,Reprod. Nutr. Dev., 1987, vol. 27, pp. 865–896.

    Article  PubMed  CAS  Google Scholar 

  • Thomas, J.H., Genomic Imprinting Proposed as a Surveillance Mechanism for Chromosome Loss,Proc. Natl. Acad. Sci. USA, 1995, vol. 92, pp. 480–482.

    Article  PubMed  CAS  Google Scholar 

  • Thompson, E.M., Legouy, E., Christians, E., and Renard, J.-P., Progressive Maturation of Chromatin Structure RegulatesHSP70.1 Gene Expression in the Preimplantation Mouse Embryo,Development, 1995, vol. 121, pp. 3425–3437.

    PubMed  CAS  Google Scholar 

  • Thomson, J.A. and Solter, D., The Developmental Fate of Androgenetic, Parthenogenetic, and Gynogenetic Cells in Chimeric Gastrulating Mouse Embryos,Genes Dev., 1988, vol. 2, pp. 1344–1351.

    Article  PubMed  CAS  Google Scholar 

  • Thomson, J.A. and Solter, D., Chimeras between Parthenogenetic or Androgenetic Blastomeres and Normal Embryos: Allocation to the Inner Cell Mass and Trophectoderm,Dev. Biol., 1989, vol. 131, pp. 580–583.

    Article  PubMed  CAS  Google Scholar 

  • Torres, M., Stoykova, A., Huber, O.,et al., An E-Catenin Gene Trap Mutation Defines Its Function in Preimplantation Development,Proc. Natl. Acad. Sci. USA, 1997, vol. 94, pp. 901–906.

    Article  PubMed  CAS  Google Scholar 

  • Trasler, J.M., Trasler, D.G., Bestor, T.H.,et al., DNA Methyltransferase in Normal andDnmtn/Dnmtn Mouse Embryos,Dev. Dyn., 1996, vol. 206, pp. 239–247.

    Article  PubMed  CAS  Google Scholar 

  • Van Blerkom, J., The Structural Relation and Posttranslational Modification of Stage Specific Proteins Synthesized during Early Preimplantation Development in the Mouse,Proc. Natl. Acad. Sci. USA, 1981, vol. 78, pp. 7629–7633.

    Article  PubMed  Google Scholar 

  • Van Blerkom, J., Microtubule Mediation of Cytoplasmic and Nuclear Maturation during the Early Stages of Resumed Meiosis in Cultured Mouse Oocytes,Proc. Natl. Acad. Sci. USA, 1991, vol. 88, pp. 5031–5035.

    Article  PubMed  Google Scholar 

  • Van Blerkom, J. and Bell, H., Regulation of Development in the Fully Grown Mouse Oocyte: Chromosome-Mediated Temporal and Spatial Differentiation of the Cytoplasm and Plasma Membrane,J. Embryol. Exp. Morphol., 1986, vol. 93, pp. 213–238.

    PubMed  Google Scholar 

  • Varmuza, S. and Mann, M., Genomic Imprinting—Defusing the Ovarian Time Bomb,Trends Genet., 1994, vol. 10, pp. 118–123.

    Article  PubMed  CAS  Google Scholar 

  • Waddington, C.H.,Organizatory i geny (Organizers and Genes), Moscow: Gos. Izd. Inostr. Lit., 1947.

    Google Scholar 

  • Waddington, C.H.,Principles of Embryology, London: Allen & Unwin, 1956.

    Google Scholar 

  • Wakasugi, N., A Genetically Determined Incompatibility System between Spermatozoa and Eggs Leading to Embryonic Death in Mice,J. Reprod. Fertil., 1974, vol. 41, pp. 85–96.

    PubMed  CAS  Google Scholar 

  • Wakasugi, N., Tomita, T., and Kondo, K., Differences of Fertility in Reciprocal Crosses between Inbred Strains of Mice: DDK, KK, and NC,J. Reprod. Fertil., 1967, vol. 13, pp. 41–50.

    Article  PubMed  CAS  Google Scholar 

  • Wakayama, T., Perry, A.C.F., Zuccotti, M.,et al., Full-Term Development of Mice from Enucleated Oocytes Injected with Cumulus CeNI Nuclei,Nature, 1998, vol. 394, pp. 369–374.

    Article  PubMed  CAS  Google Scholar 

  • Waksmundska, M., Krysiak, E., Karasiewicz, J.,et al., Autonomous Cortical Activity in Mouse Eggs Controlled by a Cytoplasmic Clock,J. Embryol. Exp. Morphol., 1984, vol. 79, pp. 77–96.

    Google Scholar 

  • Wang, Q. and Latham, K.E., Requirement for Protein Synthesis during Embryonic Genome Activation in Mice,Mol. Reprod. Dev., 1997, vol. 47, pp. 265–270.

    Article  PubMed  CAS  Google Scholar 

  • Warner, C.M., Exley, G.E., McElhinny, A.S., and Tang, C., Genetic Regulation of Preimplantation Mouse Embryo Survival,J. Exp. Zool., 1998, vol. 282, pp. 272–279.

    Article  PubMed  CAS  Google Scholar 

  • Watson, A.J., The Cell Biology of Blastocyst Development,Mol. Reprod. Dev., 1992, vol. 33, pp. 492–504.

    Article  PubMed  CAS  Google Scholar 

  • Watson, A.J. and Kidder, G.M., Immunofluorescence Assessment of the Timing of Appearance and Cellular Distribution of Na/K-ATPase during Mouse Embryogenesis,Dev. Biol., 1988, vol. 126, pp. 80–90.

    Article  PubMed  CAS  Google Scholar 

  • Watson, A.J., Damsky, C.H., and Kidder, G.M., Differentiation of an Epithelium: Factors Affecting the Polarized Distribution of Na+,K+-ATPase during Mouse Embryogenesis,Dev. Biol., 1990a, vol. 141, pp. 104–114.

    Article  PubMed  CAS  Google Scholar 

  • Watson, A.J., Pape, C., Emanuel, J.R.,et al., Expression of Na+,K+-ATPase and Subunit Genes during Preimplantation Development of the Mouse,Dev. Genet., 1990b, vol. 11, pp. 41–48.

    Article  PubMed  CAS  Google Scholar 

  • Webb, M., Howlett, S.K., and Maro, B., Parthenogenesis and Cytoskeletal Organization in Aging Mouse Eggs,J. Embryol. Exp. Morphol., 1986, vol. 95, pp. 131–145.

    PubMed  CAS  Google Scholar 

  • Werb, Z., Expression of EGF and TGF-(Genes in Early Mammalian Development,Mol. Reprod. Dev., 1990, vol. 27, pp. 10–15.

    Article  PubMed  CAS  Google Scholar 

  • Werren, J.H. and Beukeboom, L.W., Sex Determination, Sex Ratios, and Genetic Conflict,Annu. Rev. Ecol. Syst., 1998, vol. 29, pp. 233–261.

    Article  Google Scholar 

  • Wiekowski, M., Miranda, M., and DePamphilis, M.L., Regulation of Gene Expression in Preimplantation Mouse Embryos: Effects of the Zygotic Clock and the First Mitosis on Promoter and Enhancer Activities,Dev. Biol., 1991, vol. 147, pp. 403–414.

    Article  PubMed  CAS  Google Scholar 

  • Wolffe, A.P., Packaging Principle: How DNA Methylation and Histone Acetylation Control the Transcriptional Activity of Chromatin,J. Exp. Zool., 1998, vol. 282, pp. 239–244.

    Article  PubMed  CAS  Google Scholar 

  • Worrad, D.M., Ram, P.T., and Schultz, R.M., Regulation of Gene Expression in the Mouse Oocyte and Early Preimplantation Embryo: Developmental Changes in Sp1 and TATA Box Binding Protein, TBP,Development, 1994, vol. 120, pp. 2347–2357.

    PubMed  CAS  Google Scholar 

  • Yamazaki, K., Suzuki, R., Hojo, E.,et al., Trypsin-Like Hatching Enzyme of Mouse Blastocysts: Evidence for Its Participation in Hatching Process before Zona Shedding of Embryos,Dev. Growth Differ., 1994, vol. 36, pp. 149–154.

    Article  CAS  Google Scholar 

  • Zamboni, L., Ultrastructure of Mammalian Oocytes and Ova,Biol. Reprod., 1970, vol. 2, suppl., pp. 44–63.

    Article  PubMed  CAS  Google Scholar 

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Evsikov, A.V. Mechanisms of regulation of early embryogenesis. Russ J Dev Biol 31, 142–153 (2000). https://doi.org/10.1007/BF02758818

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