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L-N-(3,5-Dimethoxybenzoyl)isoleucine chiral stationary phase for separation of enantiomers by HPLC

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Summary

L-N-(3,5-dimethoxyoxybenzoyl)isoleucine, ionically bonded to γ-aminopropyl silica, has been tested as a chiral stationary phase for the separation of racemates by HPLC. The phase shows good selectivity towards different types of racemates and in particular for those having an electron-poor aromatic group in their molecule. The separation of benzoin racemate can be achieved on the developed chiral phase with an α value of 1.10.

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Authors and Affiliations

  1. Laboratory for Analytical Chemistry, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV, Amsterdam, The Netherlands

    W. J. Vloon, C. Siekerman & J. C. Kraak

Authors
  1. W. J. Vloon
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  2. C. Siekerman
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  3. J. C. Kraak
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Vloon, W.J., Siekerman, C. & Kraak, J.C. L-N-(3,5-Dimethoxybenzoyl)isoleucine chiral stationary phase for separation of enantiomers by HPLC. Chromatographia 24, 655–658 (1987). https://doi.org/10.1007/BF02688562

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  • DOI: https://doi.org/10.1007/BF02688562

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