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Corrective effect of clotrimazole and β-ionol during exposure to thiophenol

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Toxic effect of thiophenol on rats can be prevented by injection of antioxidant β-ionol and clotrimazole, an inductor of phase I and II detoxication enzymes. Both agents increase O-demethylase activity of cytochrome P-450, but do not prevent inhibition of its water-soluble form, and activate cytosol and microsomal glutathione-dependent enzymes. Both agents protected erythrocytes from peroxide damage by thiophenol and simultaneously enhanced its prooxidant effect in the liver.

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Authors and Affiliations

  1. I.I. Metchnikov St. Petersburg State Medical Academy, St. Petersburg, Russia

    V. A. Dadali, N. E. Golovanova, R. N. Pavlova, N. E. Dzhangulova & V. E. Vinogradova

Authors
  1. V. A. Dadali
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  2. N. E. Golovanova
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  3. R. N. Pavlova
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  4. N. E. Dzhangulova
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  5. V. E. Vinogradova
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Additional information

Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 130, No. 11, pp. 555–557, November, 2000

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Dadali, V.A., Golovanova, N.E., Pavlova, R.N. et al. Corrective effect of clotrimazole and β-ionol during exposure to thiophenol. Bull Exp Biol Med 130, 1090–1092 (2000). https://doi.org/10.1007/BF02688187

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  • DOI: https://doi.org/10.1007/BF02688187

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