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Basic considerations on treatment of increased platelet aggregation in diabetic vasculopathic patients

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Summary

Diabetics with vascular disorders often show changes of platelet adhesiveness as a result of which the minimum amount of ADP capable of inducing irreversible platelet aggregation is smaller than in normal subjects. A plasma component appears to be responsible for this anomaly. Acetylsalicylic acid, ditazol, papaverine, and dipyridamole are apt to suppress this excessive aggregationin vitro. It added to the plasma of diabetics showing excessive adhesiveness, the hyperaggregating effect of this plasma on normal platelets is suppressed. Papaverine retains this property even after dialysis of the plasma to which it had been added, dipyridamole and acetylsalicylic acid lose it, while ditazol occupies an intermediate position. For acetylsalicylic acid this property has been demonstratedin vivo as well, after oral administration to diabetic patients with hyperaggregation.

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Authors and Affiliations

  1. Cattedra di Terapia Medica Sistematica, Istituto di Clinica Medica Generale, Università Cattolica Del Sacro Cuore, Roma

    Bruno Bizzi, Giuseppe Leone & Paolo Boni

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  1. Bruno Bizzi
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  2. Giuseppe Leone
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  3. Paolo Boni
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Bizzi, B., Leone, G. & Boni, P. Basic considerations on treatment of increased platelet aggregation in diabetic vasculopathic patients. Acta diabet. lat 11, 437–445 (1974). https://doi.org/10.1007/BF02624583

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  • DOI: https://doi.org/10.1007/BF02624583

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