Summary
The results of two kinetic studies examining soft tissue, cartilage and bone after uptake of oral ofloxacin [administered as 200 mg twice daily (study I/nose) or 400 mg once daily (study II/ear)] show that antibiotic concentrations lie within the therapeutic range. Findings demonstrate that 400 mg ofloxacin daily is a compliance-enhacing and effective approach to the treatment of ENT-related infections, in particular those caused by problem organisms such asPseudomonas aeruginosa.
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Tolsdorff, P. Concentrations of ofloxacin in ear and nasal tissues. Eur Arch Otorhinolaryngol 250 (Suppl 1), S7–S11 (1993). https://doi.org/10.1007/BF02540109
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DOI: https://doi.org/10.1007/BF02540109