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Control parameters of the blood-pressure regulatory system

Part 2—Open-loop gain, reference pressure and basal heartrate

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Abstract

The open-loop gainG 0 reference pressureP 0 and basal heartrateR 0 of the blood-pressure regulatory system have been estimated under four different experimental conditions by employing an aortic balloon and assuming a theoretical approach based on a 1st-order linear model. Mean values of 1·7–3·7, 75–130 mmHg, and 95–130 beats/min were obtained forG 0,P 0 andR 0, respectively. Significant variations in these parameters were observed when the anaesthetic conditions were changed. It is suggested thatG 0,P 0 andR 0 may have useful clinical applications both in characterising hypotensive and hypertensive syndromes and also in assessing the effect of anaesthetic agents.

Sommaire

Les pré-ventre ouvertr 0, pression de référencep 0 et taux cardiaquer 0 du système régulatoire de la pression sanguine ont été estimés sous quatre condition expérimentales différentes en employant un ballon aortique et en présumant un abordage théorique basé sur un modèle linéaire du premier ordre. Des valeurs moyennes de 1,7 à 3,7, 75 à 130 mmHg et 95 à 130 battements/minute furent obtenus respectivement pourg 0,p 0, etr 0. Des variations significatives de ces paramètres ont été observées lors du changement des conditions anesthésiques. Il est suggéré queg 0,p 0, etr 0 puissent avoir des applications cliniques pour la caractérisation à la fois des syndromes hypotensif et hypertensif et aussi pour l'évaluation des effets d'agents anesthésiques.

Inhaltsangabe

Der offene schleifengewinng 0, der Bezugsdruckp 0 und die Basalherzfrequenzr 0 des blutdruckregelnden Systems wurden unter vier verschiedenen Versuchsbedingungen mit Hilfe eines Aortenballons geschätzt, wobei von einer auf ein lineares Modell erster Ordnung begründeten theoretischen Betrachtungsweise ausgegangen wurde. Fürg 0,p 0 undr 0 wurden Durchschnittswette von 1,7–3,7, bzw. 75–130 mmHg und 95–130 Schlägen/min ermittelt. Beträchtliche Schwankungen dieser Parameter wurden beobachtet, wenn die Anästhesieverhältnisse geändert wurden. Es wird vermutet, daßg 0,p 0 undr 0 sowohl bei der Charakterisierung hypotonischer und hypertonischer, Syndrome als auch bei der, Beurteilung der Wirkung von Anästhetica nützliche klinische Anwendungsmöglichkeiten bieten könnten.

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Valentinuzzi, M.E., Powell, T., Hoff, H.E. et al. Control parameters of the blood-pressure regulatory system. Med. & biol. Engng. 10, 596–608 (1972). https://doi.org/10.1007/BF02476077

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  • DOI: https://doi.org/10.1007/BF02476077

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