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A lipophilic adjuvant carrier system for antigenic peptides

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Abstract

A lipoamino acid based synthetic peptide, (Lipid Core Peptide, LCP) derived from the conserved region of group A streptococci (GAS) was evaluated as potential candidate in a vaccine to prevent GAS-associated diseases, including rheumatic heart disease and post-streptococcal acute glomerulonephritis. Multiple copies of a peptide sequence from the bacterial surface M protein were incorporated into a lipid core and it was used to immunize mice with and without the application of adjuvant. The LCP construct had significantly enhanced immunogenicity compared with the monomeric peptide epitope. Furthermore, the peptides incorporated into the LCP system generated antibodies without the use of any conventional adjuvant.

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References

  1. Wiesmuller, K.H., Bessler, W. and Jung, G., Hoppe Seylers Z. Physiol. Chem., 364 (1983) 593.

    Google Scholar 

  2. Tam, J.P. and Lu, Y.-A., Proc. Natl. Acad. Sci. USA, 86 (1989) 9084.

    Google Scholar 

  3. Toth, I., Danton, M., Flinn, N. and Gibbons, W.A., Tetrahedron Lett., 34 (1993) 3925.

    Google Scholar 

  4. France, L.L., Piatti, P.G., Newman, J.F.E., Gibbons, W.A., Toth, I. and Brown, F., Proc. Natl. Acad. Sci. USA, 91 (1994) 8442.

    Google Scholar 

  5. Toth, I., Flinn, N., Gibbons, W.A., Good, M., Hayman, W. and Brown, F., in Pravin T.P. Kaumaya and Robert S. Hodges (Eds), Peptides: Chemistry, Structure and Biology, Mayflower Scientific Ltd., 1996, pp. 810–811.

  6. Zong, G., Toth, I., Reid, R. and Brunham, R.C., J. Immunol., 151 (1993) 3728.

    Google Scholar 

  7. Bisno, A.L., New England J. Med., 325 (1994) 783.

    Google Scholar 

  8. Fischetti, V.A., Scientific American, 264 (1991) 32.

    Google Scholar 

  9. Fischetti, V.A., Clin. Microbiol. Rev., 2 (1989) 285.

    Google Scholar 

  10. Robinson, J.H., Kehoe, A., Immunol. Today, 13 (1992) 362.

    Google Scholar 

  11. Brandt, E.R., Sriprakash, K.S., Hobb, R.I., Hayman, W.A., Zeng, W., Batzloff, M.R., Jackson, D.C. and Good, M.F., Nature Medicine, 6 (2000) 455.

    Google Scholar 

  12. Schnölzer, M., Alewood, P., Jones, A., Alewood, D. and Kent, S.B.H., Int. J. Pept. Prot. Res., 40 (1992) 180.

    Google Scholar 

  13. Sarin, V.K., Kent, S.B.H., Tam, J.P. and Merrifield, R.B., Anal. Biochem., 117 (1981) 147.

    Google Scholar 

  14. Gibbons, A.W., Hughes, R.A., Szeto, A., Charalambous, M., Aulabaugh, A., Mascagni, P. and Toth, I., Liebigs Ann. Chem., (1990) 1175.

  15. Stewart, J.M. and Young, J.D. (Eds), Solid Phase Peptide Synthesis, 2nd ed., Pierce Chemical Company, Rockford, Illinois, 1984.

    Google Scholar 

  16. Cohen, S.A. and Michaud, D.P., Anal. Biochem., 211 (1993) 279.

    Google Scholar 

  17. Pruksakorn, S., Galbraith, A., Houghten, R.A. and Good, M.F., J. Immunol., 149 (1992) 2729.

    Google Scholar 

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Authors and Affiliations

  1. School of Pharmacy, The University of Queensland, Brisbane, Australia

    Anikó Horváth (On leave), Allan Wong & Istvan Toth

  2. Joint Research Organization of the Hungarian Academy of Sciences, Semmelweis University Budapest, Budapest, Hungary

    Colleen Olive, Timothy Clair, Penny Yarwood & Michael Good

  3. Cooperative Research Centre for Vaccine Technology, The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane QLD, Australia

    Anikó Horváth (On leave)

Authors
  1. Anikó Horváth
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  2. Colleen Olive
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  3. Allan Wong
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  4. Timothy Clair
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  5. Penny Yarwood
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  6. Michael Good
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  7. Istvan Toth
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Correspondence to Istvan Toth.

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Horváth, A., Olive, C., Wong, A. et al. A lipophilic adjuvant carrier system for antigenic peptides. Letters in Peptide Science 8, 285–288 (2001). https://doi.org/10.1023/A:1016296106387

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  • DOI: https://doi.org/10.1023/A:1016296106387

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