Abstract
The tetrapeptide tuftsin (Thr-Lys-Pro-Arg) injected intraperitoneally into cats altered the bioelectrical activity of sensory, motor, and limbicoreticular structures in the wakeful state, during two different phases of sleep, and also when the caudate nucleus was electrically stimulated. In wakefulness and during REM sleep, absolute values of the electroencephalographic power spectrum were increased in all the brain structures under study, while during slow-wave sleep they were increased in the sensorimotor cortical areas and decreased in the central medial thalamic nuclei and hippocampus. Tuftsin facilitated the genesis of slow waves in subcortical structures and the expression of theta waves in the hippocampus. It also increased the amplitude of evoked potentials and elongated spindles when the caudate nucleus was stimulated.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
L. M. Gershtein, E. L. Dovedova, A. S. Kamysheva,et al., Vopr. Med. Khimii,36, No 4, 15–17 (1990).
E. L. Dovedova, L. M. Kachalova, and E. I. Orlova,Zh. Nevropatol. Psikhiatr.,86, No 7, 1025–1028 (1986).
A. D. Kaminskii, Ya. V. Antonova, N. A. Samuilova,et al., Byull. Eksp. Biol. Med.,90, No 7, 43–45 (1980).
E. F. Lavretskaya, I. P. Ashmarin, V. N. Kalikhevich,et al., Farmakol. Toksikol., No 9, 275–279 (1981).
Z. S. Nikitina and I. A. Sytinskii,Neirokhimiya,3, No 3, 276–279 (1984).
C. D. Black and P. Winn,J. Neurosci.,13, No 3, 1035–1044 (1993).
P. W. Everett, R. M. Kemm, and J. S. McKenzie, in:The Basal Ganglia: Structure and Function, Eds. J. S. McKenzieet al., New York-London (1984), pp. 235–245.
A. M. Graybiel,Trends Neurosci. 13, No 7, 244–254 (1990).
M. Morelli M. L. Proceddu, and G. Di Chiara,Brain Res.,191, No 1, 67–78 (1980).
R. Rocchi, L. Biondi, E. Filiza,et al., Int. J. Pept. Protein Res.,37, No 2, 161–166 (1991).
B. Rousaire-Dubois, E. C. Hammond, J. Yelnik,et al., in:The Basal Ganglia: Structure and Function, Eds. J. S. McKenzieet al., New York-London (1984), pp. 205–234.
I. Z. Siemion, E. Nawrocka, J. Slon,et al., Pol. J. Pharmacol. Pharmaceut.,42, No 3, 393–401 (1990).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, vol. 119, No 4, pp. 365–368, April, 1995
Rights and permissions
About this article
Cite this article
Veskov, R., Popova, N.S., Ostojch, S. et al. Effect of the tetrapeptide tuftsin on the bioelectrical activity of brain structures in cats with different functional states of the central nervous system. Bull Exp Biol Med 119, 352–355 (1995). https://doi.org/10.1007/BF02445890
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02445890