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The diagnostic value of salivary fluid levels of β2-microglubulin, lysozyme and lactoferrin for primary Sjögren's synrome

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Summary

In search of a simple non-invasive diagnostic test for primary Sjögren's syndrome (SS) the concentration of β2-microglobulin (β2-m), lyzozyme (LZM) and lactoferrin (Lf) was measured in stimulated parotid saliva of 39 patients with primary SS, 42 patients suspected of the syndrome in whom the diagnosis could be excluded (NON-SS) and in 41 normal control individuals. Salivary fluid levels of β2-m, LZM and Lf exceeding the mean+2×standard deviation of healthy control valuese were found in respectively 58%, 23%, and 26% of the primary SS patients and in 7%., 11% and 0% of the NON-SS patients. The results of this study inndicate that due to the low sensitivity the tests are not suitable as a screening procedure for patients suspected of having primary SS However, measurement of β2-m in stimulated parotid saliva may be used as an adjunctive diagnostic test for primary SS.

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Authors and Affiliations

  1. Department of Rheumatology, Dr. Daniël Den Hoed Clinic, P.O. Box 5201, 3008 AE, Rotterdam, The Netherlands

    H. M. Markusse

  2. Department of Pathology, Dr. Daniël Den Hoed Clinic, P.O. Box 5201, 3008 AE, Rotterdam, The Netherlands

    Th. M. Vroom

  3. Department of Dentistry, Dr. Daniël Den Hoed Clinic, P.O. Box 5201, 3008 AE, Rotterdam, The Netherlands

    N. Fokkens

  4. Department of Rheumatology, University Hospital Leiden, The Netherlands

    H. G. Otten, T. J. M. Smeets & F. C. Breedveld

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  1. H. M. Markusse
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  2. H. G. Otten
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  3. Th. M. Vroom
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  4. T. J. M. Smeets
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  5. N. Fokkens
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  6. F. C. Breedveld
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Markusse, H.M., Otten, H.G., Vroom, T.M. et al. The diagnostic value of salivary fluid levels of β2-microglubulin, lysozyme and lactoferrin for primary Sjögren's synrome. Clin Rheumatol 11, 521–525 (1992). https://doi.org/10.1007/BF02283111

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  • DOI: https://doi.org/10.1007/BF02283111

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