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99mTc-DTPA aerosol for same-day post-perfusion ventilation imaging: Results of a multicentre study

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Abstract

A multicentre study was performed in an attempt to evaluate a submicronic technetium-99m diethylene triamine penta-acetic acid aerosol generated by a newly developed delivery system, the aerosol production equipment (APE nebulizer), for same-day post-perfusion ventilation imaging in patients with clinically suspected pulmonary embolism. Quantitative comparison between the DTPA aerosol and krypton gas demonstrated a close correlation with respect to regional pulmonary distribution of activity and peripheral lung penetration (n=14,r=0.94,P<0.001 andr=0.75,P<0.0025, respectively). In 169 consecutive patients, DTPA aerosol images performed immediately following perfusion (inhalation scan I) were compared to those carried out on the next day (inhalation scan 11) with respect to image quality and assessment of perfusion-ventilation matches or mismatches. Agreement between inhalation scans I and II with respect to perfusion defects matched or mismatched to ventilation was found in 166/169 (98%) studies. The image quality of inhalation scan I was equal to that of scan II in 72%; inhalation scan I was superior in 11% of cases, while scan 11 was superior in 17%. This submicronic99mTc-labelled DTPA aerosol is well suited for fast same-day post-perfusion ventilation imaging in patients with clinical suspicion of pulmonary embolism.

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References

  • Alderson PO, Martin EC (1987) Pulmonary embolism: diagnosis with multiple imaging modalities. Radiology 164:297–312

    PubMed  Google Scholar 

  • Biello DR, Mattar AG, McKnight RC, Siegel BA (1979) Ventilation-perfusion studies in suspected pulmonary embolism. AJR 133:1033–11037

    PubMed  Google Scholar 

  • Coon WW, Colter FA (1959) Clinico-pathologic correlation in thromboembolism. Surg Gynecol Obstet 109:259–269

    PubMed  Google Scholar 

  • Cooper TJ, Hayward MWJ, Hartog M (1991) Survey on the use of pulmonary scintigraphy and angiography for suspected pulmonary thromboembolism in the UK. Clin Radiol 43:243–245

    PubMed  Google Scholar 

  • Gray HW (1990) Controversies in nuclear medicine. Nucl Med Commun 11:154–157

    PubMed  Google Scholar 

  • Gray HW (1991) Editorial: The single perfusion abnormality: Quo vadis? Nucl Med Commun 12:377–379

    PubMed  Google Scholar 

  • Havig O (1977) Deep vein thrombosis and pulmonary embolism. Acta Chir Scand 478[Suppl]:1–92

    Google Scholar 

  • Huisman MV, Büller HR, ten Cate JW, van Royen EA, Vreeken J, Kersten MJ, Bakx R (1989) Unexpected high prevalence of silent pulmonary embolism in patients with deep venous thrombosis. Chest 95:498–502

    PubMed  Google Scholar 

  • Hull RD, Raskob GE, Coates G, Panju AA (1990) Clinical validity of a normal perfusion lung scan in patients with suspected pulmonary embolism. Chest 97:23–26

    PubMed  Google Scholar 

  • Köhn H, Köhler D (1990) Diagnostic modalities for detection of pulmonary embolism in clinical routine: a European survey. Lung 168[Suppl]:833–840

    PubMed  Google Scholar 

  • Köhn H, König B, Mostbeck A (1987) Incidence and clinical feature of pulmonary embolism in patients with deep vein thrombosis. Eur J Nucl Med 13:S11-S15

    Article  PubMed  Google Scholar 

  • Köhn H, de Jong R, König B, Mostbeck A (1988) Aerosol delivery system with high lung deposition efficiency. J Aerosol Med 1:227

    Google Scholar 

  • Köhn H, Armbruster C, König B, Vetter N, Mostbeck A (1989) Value of nuclear medicine procedures for diagnosis and monitoring of opportunistic lung infections in AIDS patients. Eur J Nucl Med 15:442

    Google Scholar 

  • Mason GR, Duane GB, Mena I, Effros RM (1987) Accelerated solute clearance inPneumocystis carinii pneumonia. Am Rev Respir Dis 135:864–868

    PubMed  Google Scholar 

  • Miller RF, Jarritt PH, Lui D, Kidery J, Semple SJG, Ell PJ (1991) The APE nebuliser — a new delivery system for the alveolar targeting of particulate technetium 99m diethylene triamine penta-acetic acid. Eur J Nucl Med 18:164–170

    Article  PubMed  Google Scholar 

  • Morrell MT, Dunnill MS (1968) The post-mortem incidence of pulmonary embolism in a hospital population. Br J Surg 55:347–352

    PubMed  Google Scholar 

  • Rinderknecht JL, Shapiro L, Krauthammer M, Taplin GV, Wasserman K, Uszler JM (1980) Accelerated clearance of small solutes from the lungs in interstitial lung diseases. Am Rev Respir Dis 121:105–117

    PubMed  Google Scholar 

  • Uhland H, Goldberg LM (1966) Pulmonary embolism; a commonly missed clinical entity. Dis Chest 45:533–538

    Google Scholar 

  • White PG, Hayward MWJ, Cooper T (1991) Ventilation agents — what agents are currently used? Nucl Med Commun 12:349–352

    PubMed  Google Scholar 

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Köhn, H., Mostbeck, A., Bachmayr, S. et al. 99mTc-DTPA aerosol for same-day post-perfusion ventilation imaging: Results of a multicentre study. Eur J Nucl Med 20, 4–9 (1993). https://doi.org/10.1007/BF02261238

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  • DOI: https://doi.org/10.1007/BF02261238

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