Abstract
A multicentre study was performed in an attempt to evaluate a submicronic technetium-99m diethylene triamine penta-acetic acid aerosol generated by a newly developed delivery system, the aerosol production equipment (APE nebulizer), for same-day post-perfusion ventilation imaging in patients with clinically suspected pulmonary embolism. Quantitative comparison between the DTPA aerosol and krypton gas demonstrated a close correlation with respect to regional pulmonary distribution of activity and peripheral lung penetration (n=14,r=0.94,P<0.001 andr=0.75,P<0.0025, respectively). In 169 consecutive patients, DTPA aerosol images performed immediately following perfusion (inhalation scan I) were compared to those carried out on the next day (inhalation scan 11) with respect to image quality and assessment of perfusion-ventilation matches or mismatches. Agreement between inhalation scans I and II with respect to perfusion defects matched or mismatched to ventilation was found in 166/169 (98%) studies. The image quality of inhalation scan I was equal to that of scan II in 72%; inhalation scan I was superior in 11% of cases, while scan 11 was superior in 17%. This submicronic99mTc-labelled DTPA aerosol is well suited for fast same-day post-perfusion ventilation imaging in patients with clinical suspicion of pulmonary embolism.
Similar content being viewed by others
References
Alderson PO, Martin EC (1987) Pulmonary embolism: diagnosis with multiple imaging modalities. Radiology 164:297–312
Biello DR, Mattar AG, McKnight RC, Siegel BA (1979) Ventilation-perfusion studies in suspected pulmonary embolism. AJR 133:1033–11037
Coon WW, Colter FA (1959) Clinico-pathologic correlation in thromboembolism. Surg Gynecol Obstet 109:259–269
Cooper TJ, Hayward MWJ, Hartog M (1991) Survey on the use of pulmonary scintigraphy and angiography for suspected pulmonary thromboembolism in the UK. Clin Radiol 43:243–245
Gray HW (1990) Controversies in nuclear medicine. Nucl Med Commun 11:154–157
Gray HW (1991) Editorial: The single perfusion abnormality: Quo vadis? Nucl Med Commun 12:377–379
Havig O (1977) Deep vein thrombosis and pulmonary embolism. Acta Chir Scand 478[Suppl]:1–92
Huisman MV, Büller HR, ten Cate JW, van Royen EA, Vreeken J, Kersten MJ, Bakx R (1989) Unexpected high prevalence of silent pulmonary embolism in patients with deep venous thrombosis. Chest 95:498–502
Hull RD, Raskob GE, Coates G, Panju AA (1990) Clinical validity of a normal perfusion lung scan in patients with suspected pulmonary embolism. Chest 97:23–26
Köhn H, Köhler D (1990) Diagnostic modalities for detection of pulmonary embolism in clinical routine: a European survey. Lung 168[Suppl]:833–840
Köhn H, König B, Mostbeck A (1987) Incidence and clinical feature of pulmonary embolism in patients with deep vein thrombosis. Eur J Nucl Med 13:S11-S15
Köhn H, de Jong R, König B, Mostbeck A (1988) Aerosol delivery system with high lung deposition efficiency. J Aerosol Med 1:227
Köhn H, Armbruster C, König B, Vetter N, Mostbeck A (1989) Value of nuclear medicine procedures for diagnosis and monitoring of opportunistic lung infections in AIDS patients. Eur J Nucl Med 15:442
Mason GR, Duane GB, Mena I, Effros RM (1987) Accelerated solute clearance inPneumocystis carinii pneumonia. Am Rev Respir Dis 135:864–868
Miller RF, Jarritt PH, Lui D, Kidery J, Semple SJG, Ell PJ (1991) The APE nebuliser — a new delivery system for the alveolar targeting of particulate technetium 99m diethylene triamine penta-acetic acid. Eur J Nucl Med 18:164–170
Morrell MT, Dunnill MS (1968) The post-mortem incidence of pulmonary embolism in a hospital population. Br J Surg 55:347–352
Rinderknecht JL, Shapiro L, Krauthammer M, Taplin GV, Wasserman K, Uszler JM (1980) Accelerated clearance of small solutes from the lungs in interstitial lung diseases. Am Rev Respir Dis 121:105–117
Uhland H, Goldberg LM (1966) Pulmonary embolism; a commonly missed clinical entity. Dis Chest 45:533–538
White PG, Hayward MWJ, Cooper T (1991) Ventilation agents — what agents are currently used? Nucl Med Commun 12:349–352
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Köhn, H., Mostbeck, A., Bachmayr, S. et al. 99mTc-DTPA aerosol for same-day post-perfusion ventilation imaging: Results of a multicentre study. Eur J Nucl Med 20, 4–9 (1993). https://doi.org/10.1007/BF02261238
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02261238