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Differential absorption of the heme and globin moieties of hemoglobin

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Summary

Studies were performed in 4 healthy men to determine the intestinal absorption and fecal excretion of the heme and the protein moieties of hemoglobin when hemoglobin was given orally in large amounts. The relatively higher absorption of the protein moiety of hemoglobin was confirmed by a proportionate increase in urinary nitrogen. These observations indicate that the role of blood loss in the pathogenesis of protein malnutrition in patients with hookworm disease is minimal.

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References

  1. Behrendt, H. Chemistry of Erythrocytes. Thomas, Springfield, 1957, p. 227.

    Google Scholar 

  2. Ebauch, F. G., Jr., andBeeken, W. L. The chemical quantitation of the daily fecal hemoglobin excretion in normals and patients with bleeding alimentary lesions.J Clin Invest 37: 889, 1958.

    Google Scholar 

  3. Ebauch, F. G., Jr., Clemens, T., Rodnan, C, andPeterson, R. F. Quantitative measurement of gastrointestinal blood loss. I. The use of radioactive Cr51 in patients with gastrointestinal disease.Amer J Med 25:169, 1958.

    Article  PubMed  Google Scholar 

  4. Andrews, J. S., andOliver Gonzalez, J. The quantitative determination of blood in human feces.J Lab Clin Med 27:122, 1942.

    Google Scholar 

  5. Ebauch, F. G., Jr., andBeeken, W. L. Quantitative measurement of gastrointestinal blood loss. II. Determination of 24 hours fecal blood loss by a chemical photospectro-metric technique.J Lab Clin Med 53:777, 1959.

    PubMed  Google Scholar 

  6. Hawk, P. B., Oser, B. L., andSummerson, W. H. “ Micro-Kjeldahl Method of Folin and Farmer.” InPractical Physiological Chemistry (ed. 13). McGraw-Hill, New York, 1954, p. 881.

    Google Scholar 

  7. Bonsnes, R. W., andTaussky, H. H. On the colorimctric determination of creatininc by the Jaffe reaction.J Biol. Chem 158:581, 1945.

    Google Scholar 

  8. Owen, J. A., Icco, B., Scanrett, F. J., andStewart, C. P. The determination of creatinine in plasma or serum and urine: A critical evaluation.Biochem 158:426, 1959.

    Google Scholar 

  9. Roche, M., Perez-Gimenez, M. F., Layrisse, M., andDipristo, E. Study of urinary and fecal excretion of radioactive chromium51 in man. Its use in the measurement of intestinal blood loss, associated with hookworm infection.J Clin Invest 36:1183, 1957.

    PubMed  Google Scholar 

  10. Mayoral, L. G., Tripathy, K., andGhitis, J. Reversible malabsorption in protein malnutrition, (abst).Amer J Clin Nutr 18:304, 1966.

    Google Scholar 

  11. Mayoral, L. G., Tripathy, K., Garcia, G.T., Klahr, S., andGhitis, J. Malabsorption in the tropics: A second look. I. The role of protein malnutrition.Amer J Clin Nutr (in. press).

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Supported in part by Grant 9R07-TW00103-05 (ICMRT Award) from the National Institutes of Health, U. S. Public Health Service.

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Tripathy, K., Garcia, F.T., Mayoral, L.G. et al. Differential absorption of the heme and globin moieties of hemoglobin. Digest Dis Sci 12, 577–581 (1967). https://doi.org/10.1007/BF02233494

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