Abstract
Osteogenic sarcoma is a rare but well documented complication of radiation therapy. To date, only 28 cases of radiation induced osteogenic sarcoma, following therapy for breast carcinoma, have been reported. Only one case of postirradiation sarcoma arising in the sternum has occurred and this followed irradiation to the neck. The subject of this article is therefore only the first reported case of osteosarcoma of the sternum, secondary to irradiation for breast carcinoma. A further unusual and unreported feature is the development of unilateral metastatic disease in the field of irradiation. Possible causes for this occurrence are discussed and the literature regarding postirradiation sarcoma is reviewed.
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References
Arlen M, Higinbotham N, Huvos A, Marcove RC, Miller T, Shah JC (1971) Radiation-induced sarcoma of bone. Cancer 28:1087
Beck A (1922) Zur Frage des Röntgensarkoms, zugleich ein Beitrag zur Pathogenese des Sarkoms. MMW 69:623
Bloch C (1962) Postradiation osteogenic sarcoma. Report of a case and review of literature. AJR 87:1151
Cade Sir S (1957) Radiation induced cancer in man. Br J Radiol 30:393
Cahan WG, Woodward HG, Higinbotham NL, Stewart FW, Coley BL (1948) Sarcoma arising in irradiated bone. Cancer 1:3
Cole L, Nowell P (1965) Radiation carcinogenesis: The sequence of events. Science 150:1782
Cruz M, Coley B, Stewart F (1957) Postradiation bone sarcoma. Report of eleven cases. Cancer 10:72
Dahlin D, Coventry M (1967) Osteogenic sarcoma. A study of six hundred cases. J Bone Joint Surg [An] 49:101
Dahlin DC, Ivins JC (1969) fibrosarcoma of bone. Cancer 23:35
Gregl A, Kienle J (1967) Sarcoma of the shoulder region after radical mastectomy and x-irradiation. Strahlentherapie 132:546
Hatcher C (1945) The development of sarcoma in bone subjected to roentgen or radium irradiation. J Bone Joint Surg 27:179
Hatfield PM, Schultz MD (1970) Postirradiation sarcoma. Radiology 96:593
Marie P, Clunet J, Raulot-Lapointe JG (1910) Contribution a l'etude du development des tumerus, malignes sur les ulceres de roentgen. Bull Assoc Fr Etude Cancer 3:406
Martland MS (1931) A general review of data gathered in a study of the radium dial painters. Am J Cancer 15:2435
Meyer J (1978) Thoracic effect of theraputic irradiation for breast carcinoma. AJR 130:877
Paunier JP, Candardjis G (1967) Sarcoma developing after radiotherapy. Radiol Clin Biol 36:249
Phillips T, Sheline G (1963) Bone sarcoma following radiation therapy. Radiology 81:992
Sabanas A, Dahlin D, Childs D, Ivins J (1956) Postradiation sarcoma of bone. Cancer 9:528
Schwartz EE, Rothstein JD (1968) Fibroscarcoma following radiation therapy. JAMA 203:134
Senyszyn JJ, Johnston AD, Jacox HW, Chu FCH (1970) Radiation induced sarcoma after treatment of breast cancer. Cancer 26:394
Sim F, Capps R, Dahlin D, Ivins J (1972) Postradiation sarcoma of bone. J Bone Joint Surg [Am] 54:1479
Sledge CB, Castleman B (1966) Osteoblastic lesion of the scapula five years after radical mastectomy. N Engl J Med 275:496
Tanner MC, Dahlin DC, Childs DS Jr (1961) Sarcoma complicating fibrous dysplasia — probable role of irradiation therapy. Oral Surg 14:837
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Young, J.W., Liebscher, L.A. Postirradiation osteogenic sarcoma with unilateral metastatic spread within the field of irradiation. Skeletal Radiol. 8, 279–283 (1982). https://doi.org/10.1007/BF02219623
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DOI: https://doi.org/10.1007/BF02219623