Summary
The enteropooling activity of soya-peptone was studied in germfree piglets. The enteropooling activity was restricted to the proximal part of the jejunum and was found to be blocked by aspirin. The hypothesis that soya-peptone acts via an increased biosynthesis/release of prostanoids was further studied using guinea-pig lung parenchyma. In this tissue soya-peptone induces the release of TXB2, which was inhibited by indomethacin (3 μM). The involvement of cholinergic, histaminergic and serotonergic pathways in the soya-peptone-mediated response was excluded, using antagonists. The conclusion was reached that soya-peptone can stimulate/modulate the biosynthesis of cyclic eicosanoids and that it exerts its enteropooling activity via the same mechanism in the jejunum of piglets.
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Jager, L.P., Zijlstra, F.J., Hoogendoorn, A. et al. Enteropooling in piglets induced by soya-peptone mediated via an increased biosynthesis of prostanoids. Vet Res Commun 10, 407–412 (1986). https://doi.org/10.1007/BF02214003
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DOI: https://doi.org/10.1007/BF02214003