Skip to main content
Log in

Ankylosing spondylitis and sarcoidosis —Coincidence or association? Case report and review of the literature

  • Case Report
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Summary

We report a 25-year-old woman presenting with sarcoidosis and bilateral sacroiliitis. Her sarcoidosis related symptoms (malaise, cough and dyspnoea) improved dramatically under treatment with steroids but severe back pain persisted. Only seven similar cases have been described over the last 40 years and the question of a possible association between the two diseases has been raised. However, prevalence data from the literature and the apparent lack of genetic links are better arguments for coincidence than for association.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Verstraeten, J.M., Bekaert, J. Association de spondylite ankylosante et de sarcoidose. Acta Tuberc Belg 1951, 42, 149–151.

    CAS  PubMed  Google Scholar 

  2. Martin, E., Fallet, G.H. Pneumopathies chroniques et rhumatisme. Schweiz Med Wochenschr 1953, 83, 776–782.

    CAS  PubMed  Google Scholar 

  3. Deshayes, P., Desseauve, J., Hubert, J., Lemercier, J.P., Geoffroy, Y. Un cas de polyarthrite au cours d'une sarcoidose. Un cas de spondylarthrite ankylosante au cours d'une sarcoidose. Rev Rhum 1965, 32, 671–674.

    CAS  PubMed  Google Scholar 

  4. Cabanel, G., Jacquot, F., Phelip, X., Gras, J.P., Mouries, D. Les formes articulaires de la sarcoidose. Sem Hôp Paris 1973, 49, 3051–3060.

    CAS  PubMed  Google Scholar 

  5. Blanchon, P., Paillas, J., Lauriat, H., Tominez, G. Localisations pelvi-rachidiennes et rachidiennes de la sarcoidose de B.B.S.. Ann Med Interne 1976, 127, 843–848.

    CAS  Google Scholar 

  6. Gerster, J.C., Chappuis, P. Association d'une sarcoïdose aguë et d'une spondylarthrite ankylosante. Schweiz Rundschau Med 1981, 70, 2356–2359.

    CAS  Google Scholar 

  7. Goldstein, R.A., Israel, H.L., Becker, K.L., Moore, C.F. The infrequency of hypercalcemia in sarcoidosis. Am J Med 1971, 51, 21–30.

    Article  CAS  PubMed  Google Scholar 

  8. Studdy, P.R., Lapworth, R., Bird, R. Angiotensin converting enzyme and its clinical significance—a review. J Clin Pathol 1983, 36, 938–947.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Costabel, U., Teschler, H., Guzman, J., Kroegel, C. Bronchoalveoläre Lavage: Zwischenbilanz nach zehn Jahren klinischer Anwendung. Med Klin 1990, 85, 367–387.

    Google Scholar 

  10. Carter, E.T. Epidemiology of ankylosing spondylitis in Rochester, Minnesota, 1935–1973. Arthritis Rheum 1979, 22, 365–370.

    Article  CAS  PubMed  Google Scholar 

  11. Teirstein, A.S., Lesser, M. Worldwide distribution and epidemiology of sarcoidosis. In: Sarcoidosis and Other Granulomatous Diseases of the Lung Vol 20. Ed.: Fanburg, B.L., Marcel Dekker, Inc 1983, 101–134.

  12. Brun, J., Pozzetto, H., Buffat, J.J., Soustelle, J., Vauzelle, J.L., Patin, R. Sarcoidose vertebrale et sarco-iliaque avec image de pseudo-abscès pottique. Presse Med 1966, 74, 511–515.

    CAS  PubMed  Google Scholar 

  13. Nowack, D., Goebel, K.M. Genetische und diagnostische Bedeutung der HLA-Merkmale bei der Sarkoidose. Schweiz Med Wschr 1986, 116, 1479–1480.

    CAS  PubMed  Google Scholar 

  14. Nowack, D., Goebel, K.M. Genetic aspects of sarcoidosis. Arch Intern Med 1987, 147, 481.

    Article  CAS  PubMed  Google Scholar 

  15. Brewerton, D.A., Cockburn, C., James, D.C., James, D.G., Neville, E. HLA antigens in sarcoidosis. Clin Exp Immunol 1977, 27, 227–229.

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Smith, M.J., Turton, C.W.G., Turner-Warwick, M., Morris, L.M., Lawler, S.D. Association of HLA B8 with spontaneus resolution in sarcoidosis. Thorax 1981, 36, 296–298.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Hedfors, E., Lindström, F. HLA-B8/DR3 in sarcoidosis. Correlation to acute onset disease with arthritis. Tissue Antigens 1983, 22, 200–203.

    Article  CAS  PubMed  Google Scholar 

  18. Kremer, J.M. Histologic findings in siblings with acute sarcoid arthritis: Association with the B8, DR3 phenotype. J Rheumatol 1986, 13, 593–597.

    CAS  PubMed  Google Scholar 

  19. Khan, M.A. HLA and ankylosing spondylitis. In: Ankylosing Spondylitis — New Clinical Applications Vol. I. Editor: Calabro, J.J., Dick C, Lancaster (England) MTP Press Limited 1987, 23.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stucki, G., Von Felten, A., Speich, R. et al. Ankylosing spondylitis and sarcoidosis —Coincidence or association? Case report and review of the literature. Clin Rheumatol 11, 436–439 (1992). https://doi.org/10.1007/BF02207214

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02207214

Key words

Navigation