Skip to main content
Log in

Visceral Leishmaniasis mimicking a flare of systemic lupus erythematosus

  • Case Report
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Summary

Fever in systemic lupus erythematosus (SLE) may be caused by exacerbation of the disease itself or by infection. We report on a patient with a long standing history of SLE that was complicated by fever and pancytopenia with no splenomegaly. SLE disease activity was suspected because of an elevated DNA-antibody titer. The early positive response to corticoid therapy may have masked the underlying infection. Visceral leishmaniasis was diagnosed by a repeated bone marrow biopsy and serological testing.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Schur, P.H. Clinical features of systemic lupus erythematous In: Textbook of Rheumatology. 3rd ed. Eds: Kelley, W.N., Harris, Jr. E.D., Ruddy, S., Sledge, C.B. Saunders WB Comp, 1989, 1101–1129.

  2. Dubois, E.L. The clinical picture of systemic lupus erythematosus. In: Dubois' Lupus Erythematosus 3rd ed. Eds: Wallace, D.J., Dubois, E.L. Philadelphia 1987 317–450.

  3. Locksley, R.M., Plorde, J.J. Leishmaniasis. In: Harrison's Principles of Internal Medicine, 2nd ed. Eds: Braunwald, E., Isselbacher, K.J., Petersdorf, R.G., Wilson J.D., Martin J.B., Fauci, A.S. Mc Graw-Hill 1987, 785–787.

  4. Martinez, L., de Letona, J., Masa Vazquez, C., Perez Maestu, R., 1st letter Senaldi, G., Cadeo, G., Carnevale, G., Di Perri, G., Carosi, G. 2nd letter: Visceral leishmaniasis as an opportunistic infection. Lancet, 1986, i, 1094.

    Google Scholar 

  5. Badaro, R., Jones, T.C., Carvalho, E.M., Sampaio, D., Reed, S.G., Barral, A., Teixera, R., Johnson, Jr. W.D. New perspectives on a subclinical form of visceral leishmaniasis. J Infect Dis 1986, 154, 1003–1011.

    PubMed  Google Scholar 

  6. Fernandez-Guerrero, M., Aguado, J., Buzon, L., Barros, C., Motalban, C., Martin, T., Bouza, E. Visceral lesishmaniasis in immunocompromised hosts. Am J Med 1987, 83, 1098–1102.

    PubMed  Google Scholar 

  7. Chulay, J.D., Bhatt, S.M., Muigai, R. et al. A comparison of three dosage regimens of sodium stibogluconate in the treatment of viscerall leishmaniasis in Kenya. J Infect Dis 1983, 148, 148–155.

    PubMed  Google Scholar 

  8. Carvalho, E.M., Bacellar, O., Barral, A., Badaro, R., Johnson, Jr W.D. Antigen-specific immunosuppression in visceral leishmaniasis is cell mediated. J Clin Invest 1989, 83, 860–864.

    PubMed  Google Scholar 

  9. Wallis, P.J.W., Clark, C.J.M. Visceral leishmaniasis complicating systemic lupus erythematosus, case report. Ann Rheum Dis 1983, 42, 201–202.

    PubMed  Google Scholar 

  10. Cohen, J., Pinching, A.J., Rees, A.J., Peters, D.K. Infection and Immunosuppression. Q J Med, 1982, 201, 1–15.

    Google Scholar 

  11. Neva, F.A. Immunotherapy for parasitic disease (editorial). N Engl J Med 1990, 322, 55–57.

    PubMed  Google Scholar 

  12. Beeson, P.B. Pyrexia of unknown origin. In: Oxford Textbook of Medicine 2nd ed., Eds: Weatherall, D.J., Ledingham, J.G.G., Warrell, D.A., Oxford University 1987, 605–608.

  13. Petersdorf, R.G., Root, R.K. Chills and Fever. In Harrison's Principles of Internal Medicine 11th ed. Eds: Braunwald, E., Isselbacher, K.J., Petersdorf, R.G., Wilson, J.D., Martin, J.B., Fauci, A.S. Mc Graw-Hill 1987, 52–56.

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Braun, J., Sieper, J., Schulte, K.L. et al. Visceral Leishmaniasis mimicking a flare of systemic lupus erythematosus. Clin Rheumatol 10, 445–448 (1991). https://doi.org/10.1007/BF02206670

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02206670

Key words

Navigation