References
American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders, 3rd edn (DSM-III). American Psychiatric Assocation, Washington, DC
Basset AS, McGillivray BC, Jones BD, Pantzar JT (1988) Partial trisomy chromosome 5 cosegregating with schizophrenia. Lancet I:799–801
Bleuler E (1911) Dementia praecox or the group of schizophrenias. Translated from the German by J Zinkin (1950). International Universities Press, New York
Bleuler M (1978) The schizophrenic disorders. Translated from the German by S Clemens. Yale University Press, New Haven
Bloom FE (1990) Strategies for understanding the role of gene defects in the pathogenesis of mental disorders. In: Bulyshenkov V, Christen Y, Prilipko L (eds) Genetic approaches in the prevention of mental disorders. Springer, Paris Berlin Heidelberg New York
Clerget-Darpoux F, Bonaiti-Pellie C, Hochez J (1986) Effects of misspecifying genetic parameters in lod score analysis. Biometrics 42:393–399
Crow TJ (1989) A pseudo-autosomal locus for the cerebral dominance gene. Lancet II:339–340
Davies KA, Read AP (1988) In: Rickwood D, Male D (eds) Molecular basis of inherited disease IRL Press, Oxford
Donis-Keller H, Green P, Helms C, Cartinhour S, Weiffenbach B, Stephens K, Keith TP, Bowden DW, et al (1987) A genetic linkage map of the human genome. Cell 51:319–337
Economou EF, Bergen AW, Warren AC, Antonarakis SE(1990) The polydeoxyadenylate tract of Alu repetitive elements in polymorphic in the human genome. Proc Natl Acad Sci USA 87:2951–2954
Edwards JH (1960) The simulation of Mendelism. Acta Genet 10:63
Farmer AE, McGuffin, P, Gottesman II (1987) Twin concordance for DSM-III schizophrenia: scrutinising the validity of the definition. Arch Gen Psychiatry 44:634–641
Gottesman II, Shields J (1982) Schizophrenia: the epigenetic puzzle. Cambridge University Press, Cambridge
Gusella JF, Wexler NS, Conneally PM, Naylor SL, Anderson MA, et al (1983) A polymorphic marker genetically linked to Huntington's disease. Nature 306:234–238
Harrison PJ, Pearson RCA (1989) Gene expression and mental disease. Psychol Med 19:813–820
Kendler KS, Gruenberg AM, Strauss JS (1981) An independent analysis of the Copenhagen sample of the Danish adoption study of schizophrenia: II. The relationship between schizotypal personality disorder and schizophrenia. Arch Gen Psychiatry 38:982–984
Kennedy JL, Guiffra LA, Moises HW, Cavalli-Sforza LL, Pakstis AJ, Kidd JR, Castiglione CM, Sjogren B, Wetterberg L, Kidd KK (1988) Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree. Nature 336:167–170
Lathrop GM, Lalouel JM (1984) Easy calculations of lod scores and genetic risks on small computers. Am J Hun Genet 36:460–465
Litt M, Luty JA (1989) A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene. Am J Hum Genet 44:397–401
McGuffin P, Farmer AE, Gottesman H (1984) Twin concordance for operationally defined schizophrenia: confirmation of familiality and heritability. Arch Gen Psychiatry 41:541–545
McGuffin P, Huckle P (1990) Simulation of Mendelism revisited. the recessive gene for attending medical school. Am J Hum Genet 46:994–999
McGuffin P, Sargeant M, Hett G, Tidmarsh S, Whatley S, Marchbanks RM (1990) Exclusion of a schizophrenia susceptibility gene from the chromosome 5q11–q13 region. New data and reanalysis of previous reports. Am J Hum Genet 47:524–535
Morton NE (1955) Sequential tests for the detection of linkage. Am J Hum Genet 7:277–318
Nakamura Y, Carlson M, Krapcho K, Kanamori M, White R (1988) New approaches for isolation of VNTR markers. Am J Hum Genet 43:854–859
Sherrington R, Brynjolfsson J, Petursson H, Potter M, Dadleston K, Barraclough B, Wasmuth J, et al (1988) Localisation of a susceptibility locus for schizophrenia on chromosome 5. Nature 336:164–167
Sturt E, McGuffin P (1985) Can linkage and marker association resolve the genetic aetiology of psychiatric disorders: review and argument. Psychol Med 15:455–462
Weber JL, May PE (1989) Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am J Hum Gen 44:388–396
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
McGuffin, P., Owen, M. The molecular genetics of schizophrenia: An overview and forward view. Eur Arch Psychiatry Clin Nuerosci 240, 169–173 (1991). https://doi.org/10.1007/BF02190759
Issue Date:
DOI: https://doi.org/10.1007/BF02190759