Summary
Six depressed patients with schizophrenia and 6 depressed patients with major depression were investigated before and during somatosensory stimulation (SS) with Tc-99m HMPAO SPECT. 8 controls were investigated only under resting conditions. The results can be summarized as follows: 1. Both psychiatric patient groups were hypofrontal (dorsolateral prefrontal cortex) compared to controls. 2. Hypofrontality was further enhanced by SS, significantly only in affective psychoses in the right inferior frontal lobe and in the right frontal hemisphere in total, in schizophrenia in the left dorsolateral prefrontal cortex. 3. Within the frontal lobes different regions were affected by SS in the two diagnostic groups. 4. In the right inferior parietal lobe SS response was significantly different in the two illnesses with schizophrenia showing a relative decrease, affective psychoses showing a relative increase of activity. 5. SS produced an increase of cerebral blood flow in subcortical regions (statistically significant contralateral to SS in thalamus and basal ganglia, ipsilateral to SS in cerebellum), a pattern which was common to all psychiatric patients. 6. Somatosensory cortex flow was not changed by SS. In conclusion, we could not fully confirm our hypotheses that similar blood flow abnormalities in different illnesses during SS are only caused by similarities in depressive psychopathology. Instead, depressed patients with schizophrenia were different from depressed patients with major depression in showing decreased activity in interrelating brain regions participating in an attentional network.
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References
Arbeitsgemeinschaft für Methodik und Dokumentation in der Psychiatrie (AMDP) (1979) Manual zur Dokumentation psychischer Befunde, 3. Aufl., Springer, Berlin Heidelberg
Asarnow RF (1982) Schizophrenia. In: Tartar (ed) The child at risk. Oxford University Press, New York
Austin MP, Dougall N, Ross M, Murray C, Carroll RE, Moffoot A, Ebmeier KP, Goodwin GM (1992) Single photon emission tomography with 99mTc exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum, J Aff Disorders 26:31–44
Baxter LR, Schwartz J, Phelps ME, Mazziotta JC, Guze BH, Selin CE, Sumida RM (1985) Cerebral metabolic rates for glucose in mood disorders. Arch Gen Psychiatry 46:441–447
Buchsbaum MS, Holcomb HH, Johnson J, King AC, Kessler R (1983) Cerebral metabolic consequences of electrical stimulation in normal individuals. Human Neurobiology 2:35–38
Buchsbaum MS, Delisi LE, Holcomb HH, Capeletti J, King AC, Johnson J, Hazlett E, Zimmermann S, Post RM, Morihisha J, Carpenter W, Cohen R, Pickar D, Weinberger DR, Margolin R, Kessler RM (1984) Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders. Arch Gen Psychiatry 41:1159–1166.
Buchsbaum MS, Wu JC, Delisi LE, Holcomb HH, Hazlett E, Cooper K, Kessler R (1987) Positron Emission Tomography studies of basal ganglia and somatosensory cortex neuroleptic drug effects. Biol Psychiatry 22:479–494
Buchsbaum MS, Nuechterlein KH, Haier RJ, Wu J, Sicotte N, Hazlett E, Ascarnow R, Potkins S, Guich S (1990) Glucose metabolic rate in normals and schizophrenics during the continuous performance test assessed by positron emission tomography. Br J Psychiatry 156:216–227
Cleghorn J, Kaplan R, Nahmias C, Garnett E, Firnau G, Brown GM, Szechtman H, Szechtman B (1989) Increased frontal and reduced parietal glucose metabolism in acute untreated schizophrenia. Psychiatry Res 28:119–133
Ebert D, Feistel H, Barocka A (1991) Effects of sleep deprivation on the limbic system and the frontal lobes in affective disorders: A study with Tc-99m-HMPAO SPECT. Psychiatry Res 40:247–251
Feistel H, Stefan H, Platsch G (1989) Tc-99m-HMPAO SPECT during seizures of focal epilepsy. In: Schmidt H, Buraggi G (eds) Nuclear Medicine, Schattauer, Stuttgart
Greenberg HJ, Reivich M, Alavi A, Hand B, Rosenquist A, Rintelmann W, Stein A, Tusa R, Dann R, Christman D, Fowler J, Macgregor B, Wolf A (1981) Metabolic mapping of functional activity in human subjects with the fluorodeoxyglucose technique. Science 212:678–680
Günther W, Petsch R, Steinberg R, Moser E, Streck P, Heller HJ, Kurtz K, Hippius H (1991) Brain dysfunction during motor activation and corpus callosum alterations in schizophrenia measured by cerebral blood flow and MRI. Biol Psychiatry 29:535–555
Ingvar DH, Rosen I, Ericksson M, Elmqvist D (1976) Activation patterns induced in the dominant hemisphere by skin stimulation. in: Zotterman Y (ed) Sensory functions of the skin, Pergamon, London, pp 549–559
Kishimoto H, Kuwahara H, Ohno S, Takazu O, Hama Y, Yokoi S, Masaaki I (1987) Three subtypes of chronic schizophrenia identified using11C-Glucose positron emission tomography. Psychiatry Res 21:285–292
Martin JH (1989) Neuroanatomy. Elsevier, New York
Martinot JL, Hardy P, Feline A, Huret J, Mazoyer P, Attar D, Pappata S, Syrota A (1990) Left prefrontal glucose hypometabolism in the depressed state. Am J Psychiatry 147:1313–1317
Mirsky AF, Duncan CC (1989) Attention impairment in human clinical disorders. In: Sheer, Pribram (eds) Attention: Theory, Brain functions and clinical applications. Erlbaum, Hillsdale
Podreka I, Suess E, Goldenberger G (1987) Initial experiences with Tc-99m-HMPAO brain-SPECT. J Nucl Med 27:1657–1666
Volkow ND, Tancredi LR (1991) Biological correlates of mental activity studied with PET. Am J Psychiatr 148:439–444
Weinberger DR, Berman KF (1988) Speculation on the meaning of cerebral metabolic hypofrontality in schizophrenia. Schizophrenia Bulletin 14:157–168
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Ebert, D., Feistel, H., Barocka, A. et al. A test-retest study of cerebral blood flow during somatosensory stimulation in depressed patients with schizophrenia and major depression. Eur Arch Psychiatry Clin Nuerosci 242, 250–254 (1993). https://doi.org/10.1007/BF02189972
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DOI: https://doi.org/10.1007/BF02189972