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Synthetic peptides related to the corticotropins (ACTH) and the melanophore stimulating hormones (MSH) possessing corticotropin releasing activity (CRF-activity)

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Zusammenfassung

Einige Peptide, strukturell ähnlich den gemeinsamen Aminosäuresequenzen der drei Hypophysenhormone ACTH, α- und β-MSH, wurden synthetisiert. Sie zeigen eine sehr schwache Wirkung auf die Melanophoren (V wurde nicht geprüft); das Heptapeptid (III) besitzt keine ACTH-Aktivität. Die drei Verbindungen II, III und V vergrössern die ACTH-Ausschüttung imin vitro-Versuch vonSaffran, Schally undBenfey 7 stark. Damit sind die ersten synthetischen Peptide mit dieser CRF-Aktivität gefunden.

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Authors and Affiliations

  1. Forschungslaboratorien der CIBA Aktiengesellschaft, Pharmazeutische Abteilung, Basel

    H. Kappeler & R. Schwyzer

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  1. H. Kappeler
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  2. R. Schwyzer
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Kappeler, H., Schwyzer, R. Synthetic peptides related to the corticotropins (ACTH) and the melanophore stimulating hormones (MSH) possessing corticotropin releasing activity (CRF-activity). Experientia 16, 415–417 (1960). https://doi.org/10.1007/BF02178842

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