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Über den Stoffwechsel der Nebennierenrindenhormone

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Summary

Three reactions, the 11β- and the 21-hydroxylation as well as the oxydation of the angular carbon 18, are specific for the adrenals. All other enzymatic steps in the biosynthesis of steroidhormones have been demonstrated in some other tissues also. Cofactors for the hydroxylation of steroids are reduced pyridinenucleotides. They seem to be necessary to activate molecular oxygen.

The extra-adrenal metabolism of adrenal hormones occurs mainly in the liver. Four principal reactions are known: the reduction of the△ 4-3-on-, the 11-keto-, and the 20-keto-group as well as the conjugation of steroids with glucuronid acid. Evidence is given that the liver is the main target of corticosteroid action.

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  1. Institut für Vegetative Physiologie der Universität, Frankfurt a. M.

    H. J. Hübener

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Hübener, H.J. Über den Stoffwechsel der Nebennierenrindenhormone. Experientia 13, 210–216 (1957). https://doi.org/10.1007/BF02157168

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