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Involvement of D-amino acid oxidase in elimination of D-serine in mouse brain

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Abstract

The physiological role of D-amino acid oxidase (EC 1. 4. 3. 3) in mouse brain is described. The presence of D-enantiomers of neutral common amino acids was surveyed in the brain. D-serine was shown to be present at high concentration only in regions where the enzyme activity was low. In normal mice whose D-amino acid oxidase activity was much higher in the cerebellum than in the cerebrum, free D-serine content was apparently lower in the cerebellum than in the cerebrum. In mice of a mutant strain lacking D-amino acid-oxidase activity, the free D-serine level was remarkably high both in the cerebrum and cerebellum. The results suggest that the enzyme is involved in the elimination of free D-serine in the cerebellum.

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  1. Department of Life Science, Himeji Institute of Technology, 2167 Shosha, 671-22, Himeji, Japan

    Y. Nagata

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  1. Y. Nagata
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Nagata, Y. Involvement of D-amino acid oxidase in elimination of D-serine in mouse brain. Experientia 48, 753–755 (1992). https://doi.org/10.1007/BF02124295

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  • DOI: https://doi.org/10.1007/BF02124295

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