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DoesHelicobacter pylori-induced gastritis enhance food-stimulated insulin release?

  • Esophageal, Gastric, And Duodenal Disorders
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

The fact thatH. pylori gastritis results in an increased secretion of basal and meal-stimulated gastrin, which is also a physiologic amplifier of insulin release directed us to investigate whetherH. pylori gastritis may lead to an enhancement of nutrient-stimulated insulin secretion. For this purpose, we have investigated the insulin responses to both oral glucose and a mixed meal in 15 patients withH. pylori gastritis before and one month after the eradication therapy and also in 15H. pylori-negative control subjects. The areas under the curve (AUC) for serum insulin following both oral glucose and a mixed meal in the patients withH. pylori gastritis before the eradication were significantly (P<0.05) higher than those in theH. pylori-negative controls. After the eradication ofH. pylori, the AUC for serum insulin following oral glucose and mixed meal decreased by 9.4% and 13.1%, respectively (P<0.001 in both), and serum basal and meal-stimulated gastrin levels decreased significantly (P<0.001). These results suggest thatH. pylori gastritis enhances glucose and meal-stimulated insulin release probably by increasing gastrin secretion.

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Authors and Affiliations

  1. From the Department of Internal Medicine, Division of Endocrinology, Division of Gastroenterology, Cerrahpaşa Medical School Hospital, University of İstanbul, Istanbul, Turkey

    Özer Açbay MD, Aykut Ferhat Çelik MD & Sadi Gündoğdu MD

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  1. Özer Açbay MD
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  2. Aykut Ferhat Çelik MD
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  3. Sadi Gündoğdu MD
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Açbay, Ö., Çelik, A.F. & Gündoğdu, S. DoesHelicobacter pylori-induced gastritis enhance food-stimulated insulin release?. Digest Dis Sci 41, 1327–1331 (1996). https://doi.org/10.1007/BF02088555

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  • DOI: https://doi.org/10.1007/BF02088555

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