Abstract
We investigated the effects of liposime-encapsulated clindamycin inStaphylococcus aureaus endophthalmitis induced in rabbits. Clindamycin was encapsulated into liposomes, and suspended in two concentrations: 1 mg/0.1 ml and 2 mg/0.1 ml of clindamycin phosphate. Seven eyes received an intravitreal injectin (0.1 ml volume) containing 1 mg of liposome-encapsulated clindamycin and seven eyes received 2 mg. Three control rabbits (six eyes) received drug-free liposomes (three eyes) and no treatment (three eyes). All but one eye treated with clindamycin recovered. All control eyes, inclduing those treated with empty lipsomes, were lost to infection.
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Rao, V.S., Peyman, G.A., Khoobehi, B. et al. Evaluation of liposome-encapsulated clindamycin inStaphylococcus aureaus endophthalmitis. Int Ophthalmol 13, 181–185 (1989). https://doi.org/10.1007/BF02028207
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DOI: https://doi.org/10.1007/BF02028207