Skip to main content
SpringerLink
Log in

In vitro activity of seventeen antimicrobial agents againstGardnerella vaginalis

  • Published:
European Journal of Clinical Microbiology Aims and scope Submit manuscript

Abstract

The in vitro activity of 17 antimicrobial agents was tested against 25 clinical isolates ofGardnerella vaginalis. Minimum inhibitory concentrations were determined by agar dilution. The isolates were sensitive to penicillin, ampicillin, ticarcillin, piperacillin, cephalothin, cefoxitin, cefotaxime, cefoperazone, N-formimidoyl-thienamycin, chloramphenicol, clindamycin and erythromycin. MIC90 for theβ-lactam antibiotics ranged from 0.12 mg/l for penicillin to 2 mg/l for ticarcillin. Cefoperazone was the most active cephalosporin, inhibiting all isolates at 1.0 mg/l. N-formimidoyl-thienamycin was the most active of the newerβ-lactam compounds inhibiting all isolates with a concentration of 0.5 mg/l. Clindamycin and erythromycin were highly active, inhibiting all isolates at 0.6 mg/l. Susceptibility to tetracycline, gentamicin, metronidazole and tinidazole varied between strains. All isolates were resistant to rosoxacin. The hydroxy-metabolites of metronidazole and tinidazole were more active than the parent compounds, inhibiting all isolates

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Gardner, H. L., Dukes, C. D.:Haemophilus vaginalis vaginitis. A newly defined specific infection previously classified “non-specific vaginitis”. American Journal of Obstetrics and Gynaecology 1955, 69: 962–976.

    Google Scholar 

  2. McCarthy, L. R., Mickelsen, P. A., Grover-Smith, E.: Antibiotic susceptibility ofHaemophilus vaginalis (Corynebacterium vaginale) of 21 antibiotics. Antimicrobial Agents and Chemotherapy 1979, 16: 186–189.

    PubMed  Google Scholar 

  3. Dobson, R. A., O'Connor, J. R., Poulin, S. A., Kundsin, R. B., Smith, T. F., Came, P. E.: In vitro antimicrobial activity of rosoxacin againstNeisseria gonorrhoeae, Chlamydia trachomatis, andUreaplasma urealyticum. Antimicrobial Agents and Chemotherapy 1980, 18: 738–740.

    PubMed  Google Scholar 

  4. Ralph, E. D., Austin, T. W., Pattison, L. M., Schieven, B. C.: Inhibition ofHaemophilus vaginalis (Corynebacterium vaginale) by metronidazole, tetracycline, and ampicillin. Sexually Transmitted Diseases 1979, 6: 199–202.

    PubMed  Google Scholar 

  5. Ralph, E. D., Amatnieks, Y. E.: Metronidazole in treatment againstHaemophilus vaginalis (Corynebacterium vaginale). Antimicrobial Agents and Chemotherapy 1980, 18: 101–104.

    PubMed  Google Scholar 

  6. Balsdon, M. J., Jackson, D.: Metronidazole metabolite andGardnerella vaginalis (Corynebacterium vaginale). Lancet 1981, i: 1112.

    Article  Google Scholar 

  7. Shanker, S., Munro, R.: Sensitivity ofGardnerella vaginalis to metabolites of metronidazole and tinidazole. Lancet 1982, i: 167.

    Article  Google Scholar 

  8. Hwang, M., Ederer, G. M.: Rapid hippurate hydrolysis method for presumptive identification of group B Streptococci. Journal of Clinical Microbiology 1975, 1: 114–115.

    PubMed  Google Scholar 

  9. Bailey, R. K., Voss, I. L., Smith, R. F.: Factors affecting isolation and identification ofHaemophilus vaginalis (Corynebacterium vaginale). Journal of Clinical Microbiology 1979, 9: 65–71.

    PubMed  Google Scholar 

  10. Greenwood, J. R., Martin, M. J., Mack, E. G.:Haemophilus vaginalis (Corynebacterium vaginale): method for isolation and rapid biochemical identification. Health Laboratory Science 1977, 14: 102–106.

    PubMed  Google Scholar 

  11. Dunkelberg, W. E., Skaggs, R., Kellogg, D. S.: Method for isolation and identification ofCorynebacterium vaginale (Haemophilus vaginalis). Applied Microbiology 1970, 19: 47–52.

    PubMed  Google Scholar 

  12. Durfee, M. A., Forsyth, P. S., Hale, J. A., Holmes, K. K.: Ineffectiveness of erythromycin for treatment ofHaemophilus vaginalis associated vaginitis: possible relationship to acidity of vaginal secretions. Antimicrobial Agents and Chemotherapy 1979, 16: 635–637.

    PubMed  Google Scholar 

  13. Smith, R. F., Dunkelberg, W. E.: Inhibition ofCorynebacterium vaginale by metronidazole. Sexually Transmitted Diseases 1977, 4: 20–21.

    PubMed  Google Scholar 

  14. Pheifer, T. A., Forsyth, P. S., Durfee, M. A., Pollock, H. M., Holmes, K. K.: Non-specific vaginitis. Role ofHaemophilus vaginalis and treatment with metronidazole. New England Journal of Medicine 1978, 298: 1429–1434.

    PubMed  Google Scholar 

  15. Balsdon, M. J., Taylor, G. E., Pead, L., Maskell, R.:Corynebacterium vaginale and vaginitis: a controlled trial of treatment. Lancet 1980, i: 501–503.

    Article  Google Scholar 

  16. Bardi, M., Manenti, G., Mattioni, D., Lasala, L.: Metronidazole for non-specific vaginitis. Lancet 1981, i: 1029.

    Google Scholar 

  17. Goei, S. H., Wells, J. I.:Corynebacterium vaginale in non-purulent vaginitis. Medical Journal of Australia 1981, 1: 470–472.

    PubMed  Google Scholar 

  18. Malouf, M., Fortier, M., Moran, G., Duke, J. L.: Treatment ofHaemophilus vaginalis vaginitis. Obstetrics and Gynecology 1981, 57: 711–714.

    PubMed  Google Scholar 

  19. Spiegel, C. A., Amsel, R., Eschenbach, D., Schoenknecht, F., Holmes, K. K.: Anaerobic bacteria in non-specific vaginitis. New England Journal of Medicine 1980, 303: 601–607.

    PubMed  Google Scholar 

  20. Taylor, E., Blackwell, A. L., Barlow, D., Phillips, I.:Gardnerella vaginalis, anaerobes, and vaginal discharge. Lancet 1982, i: 1376–1379.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Bacteriology Department, Institute of Clinical Pathology and Medical Research, PO Box 60, 2145, Wentworth-ville, New South Wales, Australia

    S. Shanker, M. Toohey & R. Munro

Authors
  1. S. Shanker
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Toohey
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Munro
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shanker, S., Toohey, M. & Munro, R. In vitro activity of seventeen antimicrobial agents againstGardnerella vaginalis . Eur. J, Clin. Microbiol. 1, 298–300 (1982). https://doi.org/10.1007/BF02019975

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02019975

Keywords

Search

Navigation