Abstract
Studiesin vitro have demonstrated histamine release induced by opioid analgesics from rat peritoneal mast cells and human skin mast cells. In humans, elevated plasma histamine levels have also been found following intravenous or oral administration. This study compared the reactivity of five opioid analgesics on mast cell suspensions obtained from porcine heart, kidneys, liver and lungs. The five compounds investigated were hydromorphone, levomethadone, morphine, pethidine and oxycodone. Both morphine and hydromorphone produced little histamine release from all cell types tested. The other drugs demonstrated clear differences between the different cell populations. Thus, the cardiac cells responded most strongly to oxycodone but were the least responsive to pethidine. These differences, if confirmedin vivo, could indicate which drugs may be more suitable for patients with different underlying disease states.
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H. Suttmann, A. Doenicke, W. Lorenz, M. Ennis, O. A. Müller, R. Dorow and M. Ackenheil,Is perioperative stress a real surgical phenomenon or merely a drug-induced effect? A study comparing the actions of nalbuphine and morphine on subjective factors and endocrinological parameters in volunteers. Theor. Surg.1, 119–135 (1986).
D. M. Philbin, J. Moss, C. E. Roscow, C. W. Akins and J. L. Rosenberger,Histamine release with intravenous narcotics: Protective effects of H 1 andH 2-receptor antagonists. Klin. Wochenschr.60, 1056–1059 (1982).
S. Berg-Seiter, B. Kossmann, W. Dick and W. Lorenz,Untersuchungen zum Verhalten der Plasmahistaminspiegel nach periduraler Morphinapplikation. Anaesthesist34, 388–391 (1985).
N. Grosman,Histamine release from isolated rat mast cells: effect of morphine and related drugs and their interaction with compound 48/80. Agents and Actions11, 196–203 (1981).
R. C. Benyon,The human skin mast cell Clin. Exp. Allergy19, 375–387 (1989).
M. Ennis,Histamine release from human pulmonary mast cells. Agents and Actions12, 60–63 (1982).
F. L. Pearce, M. Ennis, A. Truneh and J. R. White,Role of intra- and extracellular calcium in histamine release from rat peritoneal mast cells. Agents and Actions11, 51–54 (1981).
M. Ennis, W. Lorenz and W. Gerland,Modulation of histamine release from rat peritoneal mast cells by non-cytotoxic concentrations of the detergents Cremophor El ® (oxethylated castor oil) and Triton X100. A possible explanation for unexpected adverse drug reactions? Agents and Actions18, 235–238 (1986).
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Ennis, M., Schneider, C., Nehring, E. et al. Histamine release induced by opioid analgesics: A comparative study using porcine mast cells. Agents and Actions 33, 20–22 (1991). https://doi.org/10.1007/BF01993116
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DOI: https://doi.org/10.1007/BF01993116