Skip to main content
Log in

Radioprotective effects of the immunostimulating lauroylpeptide LtriP (RP 56142)

  • Research Articles
  • Published:
Experientia Aims and scope Submit manuscript

Abstract

The lipopeptide lauroyl-L-Ala-γ-D-Glu-L,L-A2pm (LtriP) increased the resistance of mice to the lethal effect of γ-ray irradiation. The radioprotective effect was dependent on the doses of LtriP and of radiation. Maximum survival was observed when the lipopeptide was injected on two successive days before irradiation. This activity seems to be related to immunostimulating functions, since the non-immunostimulating analog lauroyl-L-Ala-γ-D-Glu-D,D-A2pm-Gly, containing D,D-diaminopimelic acid, was not radioprotective. The protective activity might result from an induction of cytokines, such as IL-1, TNF and M-CSF, since LtriP induced the mRNA expression and the secretion of these immunomodulators.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature

  1. Gordon, M. Y., Aguado, M., and Blackett, N. M., Eur. J. Cancer13 (1977) 229.

    Google Scholar 

  2. Ainsworth, E. J., Pharmac. Ther.39 (1988) 223.

    Google Scholar 

  3. Patchen, M. L., D'Alesandro, M. M., Brook, I., Blakely, W. F., and MacVittie, T. J., J. Leukocyte Biol.42 (1987) 95.

    Google Scholar 

  4. Walden, T. L. Jr. Ann. N. Y. Acad. Sci.524 (1988) 431.

    Google Scholar 

  5. Neta, R., and Oppenheim, J. J., Cancer Cells3 (1991) 391.

    Google Scholar 

  6. Buc-Calderon, P., and Roberfroid, M., Experientia46 (1990) 708.

    Google Scholar 

  7. Buc-Calderon, P., and Roberfroid, M., Archs Biochem. Biophys.273 (1989) 339.

    Google Scholar 

  8. Migliore-Samour, D., Bouchaudon, J., Floc'h, F., Zerial, A., Ninet, L., Werner, G. H., and Jollès, P., Life Sci.26 (1980) 883.

    Google Scholar 

  9. Migliore-Samour, D., Delaforge, M., Jaouen, M., Mansuy, D., and Jollès, P., Experientia45 (1989) 882.

    Google Scholar 

  10. Poirier, J., Bousseau, A., Folliard, F., Molinie, B., and Terlain, B., 7th Int. Congress Immunology, Berlin, August 1989.

  11. Chomczynski, P., and Sacchi, N., Analyt. Biochem.162 (1987) 156.

    Google Scholar 

  12. Le, P. T., Vollger, L. W., Haynes, B. F., and Singer, K. H., J. Immun.144 (1990) 4541.

    Google Scholar 

  13. Floc'h, F., and Poirier, J., Int. J. Immunopharmac.10 (1988) 863.

    Google Scholar 

  14. Mishell, B. B., Shiigi, S. M., Henry, C., Chan, E. L., North, J., Gallily, R., Slomich, M., Miller, K., Marbrook, J., Parks, D., and Good, A. H., in: Selected Methods in Cellular Immunology, p. 1. Eds B. B. Mishell and S. M. Shiigi, W. H. Freeman and Co., New York, 1980.

    Google Scholar 

  15. Mosmann, T., J. immun. Meth.65 (1983) 55.

    Google Scholar 

  16. Denisot, F., and Lang, R., J. immun. Meth.89 (1986) 271.

    Google Scholar 

  17. Peto, R., and Peto, J., J. R. stat. Soc. A.135 (1972) 185.

    Google Scholar 

  18. Mori, K. J. and Nakamura, S., Experientia26 (1970) 1386.

    Google Scholar 

  19. Tsurusawa, T., Izumi, H., Fujita, J., and Mori, K. J., Experientia38 (1982) 1231.

    Google Scholar 

  20. Nose, M., Tanikawa, S., Kawase, Y., and Nakao, I., J. radiat. Res.30 (1989) 99.

    Google Scholar 

  21. Nunez, G., London, L., Hockenbery, D., Alexander, M., McKearn, J. P., and Korsmeyer, S. J., J. Immun.144 (1990) 3602.

    Google Scholar 

  22. Hockenbery, D., Zutter, M., Hickey, W., Nahm, M., and Korsmeyer, S. J., Proc. natl Acad. Sci. USA88 (1991) 6961

    Google Scholar 

  23. Sentman, C. L., Shutter, J. R., Hockenbery, D., Kanagawa, O., and Korsmeyer, S. J., Cell67 (1991) 879.

    Google Scholar 

  24. Strosser, A., Harris, A. W., and Cory, S., Cell67 (1991) 889.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Migliore-Samour, D., Bousseau, A., Caillaud, J.M. et al. Radioprotective effects of the immunostimulating lauroylpeptide LtriP (RP 56142). Experientia 49, 160–166 (1993). https://doi.org/10.1007/BF01989422

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01989422

Key words

Navigation