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The development of synthetic fungicides; trends and prospects

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Abstract

The presently available organic compounds which are being used for the combat of fungal plant diseases are reviewed.

In most cases these molecules protect the plant by killing the attacking fungus before it has penetrated the plant; consequently we are dealing here with typical fungicides. Many attempts have been made to widen the scope of this principle by the development of compounds which are able to penetrate into the plant and which, consequently, may prevent the penetration of fungi from within or which kill fungi which have already penetrated. During recent years remarkable successes have been achieved with these so-called systemic fungicides.

The newest approach is to look for compounds which are neither fungi-nor phytotoxic but which disturb the biochemical relation between a fungus and its host plant in a specific way.

These new approaches are illustrated with a few examples from recent work at the Institute for Organic Chemistry TNO at Utrecht.

Samenvatting

Een overzicht wordt gegeven van de huidige organische verbindingen welke worden gebruikt voor de bestrijding van door schimmels veroorzaakte planteziekten. Veelal geldt het moleculen die de plant beschermen door de aanvallende schimmel te doden vóór deze de plant is binnengedrongen en die dus als typische fungiciden kunnen worden beschouwd. Reeds lang heeft men getracht het werkingsbereik van dit principe te vergroten door verbindingen te ontwikkelen, die de plant kunnen binnendringen en de penetratie van schimmels van binnen uit kunnen verhinderen, resp. reeds gepenetreerde schimmels kunnen doden. Gedurende de laatste jaren zijn met deze zogenaamde systemische fungiciden opmerkelijke successen behaald.

Bij de nieuwste richtingen van onderzoek wordt gezocht naar verbindingen die niet fungi- of fytotoxisch zijn, doch die de biochemische relatie tussen een schimmel en zijn waardplant op specifieke wijze kunnen verstoren.

Ten slotte worden aan enkele voorbeelden uit het werk op het Organisch Chemisch Instituut TNO te Utrecht de nieuwe benaderingen toegelicht.

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Van Der Kerk, G.J.M. The development of synthetic fungicides; trends and prospects. Netherlands Journal of Plant Pathology 75 (Suppl 1), 5–20 (1969). https://doi.org/10.1007/BF01976649

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