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Depression of experimental gastric ulcers and acute pancreatitis in rats treated by 5-azacytosine, 5-azacytidine and their N-methyl derivatives

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Summary

5-Azacytosine, 1-methyl-5-azacytosine and 5-azacytidine administered to rats with a ligated pylorus block gastric secretion, gastric acidity, the extent of hemorrhage and the number and size of gastric defects. The same drugs also depress the development of experimental acute pancreatitis mediated in rats by interstitial administration of 7.5% natrium cholate into the pancreas in vivo. The drugs affected the amount of abdominal fluid and 6 h after the treatment the pathological changes were significantly decreased.

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Authors and Affiliations

  1. Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Prague 6

    A. Čihák, A. Pískala, L. Korbová, J. Čízková & V. Kučerová

  2. Department of Pathological Physiology, Charles University, Prague 2, Czechoslovakia

    A. Čihák, A. Pískala, L. Korbová, J. Čízková & V. Kučerová

Authors
  1. A. Čihák
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  2. A. Pískala
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  3. L. Korbová
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  4. J. Čízková
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  5. V. Kučerová
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Čihák, A., Pískala, A., Korbová, L. et al. Depression of experimental gastric ulcers and acute pancreatitis in rats treated by 5-azacytosine, 5-azacytidine and their N-methyl derivatives. Experientia 42, 32–33 (1986). https://doi.org/10.1007/BF01975880

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  • DOI: https://doi.org/10.1007/BF01975880

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