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Evidence that endogenous vasopressin plays a protective role in circulatory shock. Role for reticuloendothelial system using Brattleboro rats

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Summary

Experiments performed on male Wistar, Long Evans and Brattleboro rats indicate that the latter strain of animals, lacking vasopressin in their posterior pituitaries, are extremely sensitive to hemorrhagic and bowel ischemic shock. Mild forms of both hemorrhagic and bowel ischemic shock, as produced in Wistar on Long Evans rats, results in marked hypotension, hemoconcentration and blockade of the reticuloendothelial system (RES) in Brattleboro animals of similar sex, age and weight. These direct findings indicate that release of endogenous vasopressin in shock syndromes may be critical in maintenance of circulatory homeostasis and RES function.

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Authors and Affiliations

  1. Downstate Medical Center, Department of Physiology, State University of New York, 450 Clarkson Avenue, Box 31, 11203, Brooklyn, New York, USA

    B. M. Altura

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  1. B. M. Altura
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Additional information

Supported in part by NIH Grant Nos HL-18002 and HL-18015 and NIDA Grant No. DA-02339. The author would like to acknowledge the excellent technical assistance provided by Y. Waldemar, J. Gargani and R. W. Burton.

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Altura, B.M. Evidence that endogenous vasopressin plays a protective role in circulatory shock. Role for reticuloendothelial system using Brattleboro rats. Experientia 36, 1080–1082 (1980). https://doi.org/10.1007/BF01965981

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