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Efficacy of clindamycin/primaquine versus trimethoprim/sulfamethoxazole in primary treatment ofPneumocystis carinii pneumonia

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Abstract

Mild to moderately severePneumocystis carinii pneumonia in patients with AIDS was treated in a clinical trial with a combination regimen of primaquine and clindamycin, and the efficacy of this regimen was compared with that of the conventional treatment regimen of trimethoprim/sulfamethoxazole. The results revealed that primaquine/clindamycin appears to be an equally effective alternative to trimethoprim/sulfamethoxazole. The spectrum of side-effects was similar for the two regimens; side-effects occurred with equal frequency but appeared to be less severe in patients given primaquine/clindamycin. Because therapy with primaquine and clindamycin was limited to patients with mild to moderatePneumocystis carinii pneumonia, studies with this regimen in more severe cases are warranted.

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Authors and Affiliations

  1. Department of Internal Medicine, Department of Infectious Diseases, Rudolf Virchow University Hospital (Wedding), Freie Universität Berlin, Augustenburger Platz 1, D-1000, Berlin 65, FRG

    B. Ruf, I. Rohde & H. D. Pohle

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  1. B. Ruf
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  2. I. Rohde
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  3. H. D. Pohle
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Ruf, B., Rohde, I. & Pohle, H.D. Efficacy of clindamycin/primaquine versus trimethoprim/sulfamethoxazole in primary treatment ofPneumocystis carinii pneumonia. Eur. J. Clin. Microbiol. Infect. Dis. 10, 207–210 (1991). https://doi.org/10.1007/BF01964466

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