Summary
Ribonuclease S-protein exhibits a pH-dependent conformational transition between folded and unfolded states, and some unfolded S-protein persists up to pH 8. The histidine C2 proton resonance of the unfolded species was erroneously assigned by Bradbury et al. to histidine residue 119 of the folded species.
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References
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Shindo, H., Matsuura, S. & Cohen, J.S. Conformation of ribonuclease S-protein. Experientia 35, 1284–1285 (1979). https://doi.org/10.1007/BF01963958
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DOI: https://doi.org/10.1007/BF01963958