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Effect of meropenem on the intestinal microflora

  • New Antimicrobial Agents
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European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

Ten healthy volunteers were given 500 mg of meropenem by intravenous infusion over 30 min three times daily for seven days. Stool specimens were collected before, during and after meropenem administration. The numbers of enterobacteria and streptococci decreased during the administration period, while the numbers of enterococci increased. There was a decrease in the numbers of clostridia, bacteroides and gramnegative cocci, while the numbers of gram-positive cocci and rods were not changed by the administration of meropenem. The intestinal flora returned to normal in all volunteers within two weeks after the termination of meropenem administration.

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Authors and Affiliations

  1. Department of Microbiology, Institute of Pharmacy, University of Oslo, Oslo, Norway

    T. Bergan

  2. Department of Microbiology, Aker Hospital, Oslo, Norway

    T. Bergan

  3. Department of Microbiology, Karolinska Institute, Huddinge University Hospital, S-141 86, Huddinge, Sweden

    C. E. Nord

  4. Department of Medicine, Landspitalinn, Reykjavik, Iceland

    S. B. Thorsteinsson

Authors
  1. T. Bergan
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  2. C. E. Nord
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  3. S. B. Thorsteinsson
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Bergan, T., Nord, C.E. & Thorsteinsson, S.B. Effect of meropenem on the intestinal microflora. Eur. J. Clin. Microbiol. Infect. Dis. 10, 524–527 (1991). https://doi.org/10.1007/BF01963943

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  • DOI: https://doi.org/10.1007/BF01963943

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