Abstract
The conditions for the preparation of a 10% butyl-p-aminobenzoate suspension for epidural administration were investigated. Pharmaceutically acceptable suspensions are composed of butyl-p-aminobenzoate particles dispersed in a solvent consisting of the surfactant polysorbate 80 added to normal saline in a concentration of 0.25 mg/ml. pH Correction is not necessary. The suspensions are sterilized at 120°C followed by special milling procedures to accomplish acceptable particle size. Butyl-p-aminobenzoate suspensions are stable at 4°C during a period of at least four weeks.
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Grouls, R.J.E., Ackerman, E.W., Machielsen, E.J.A. et al. Butyl-p-aminobenzoate. Pharmaceutisch Weekblad Scientific Edition 13, 13–17 (1991). https://doi.org/10.1007/BF01963878
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DOI: https://doi.org/10.1007/BF01963878