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Comparative in vitro activity of the new oral penem ALP-201 against aerobic and anaerobic bacteria

  • New Antimicrobial Agents
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Abstract

The in vitro activity of the new penem derivative ALP-201 against 226 aerobic and 350 anaerobic clinical bacterial isolates was determined using agar dilution techniques. For comparison amoxicillin, cefaclor, ceftazidime, doxycycline, erythromycin, imipenem and trimethoprim/sulfamethoxazole were also tested with aerobic bacteria, and cefoxitin, chloramphenicol, clindamycin, imipenem, metronidazole and piperacillin with anaerobic bacteria. ALP-201 was found to be highly active againstEscherichia coli, Klebsiella spp.,Enterobacter spp.,Haemophilus influenzae, Branhamella catarrhalis, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, anaerobic cocci,Propionibacterium acnes, Clostridium perfringens, Bacteroides fragilis, Bacteroides spp. and fusobacteria.Pseudomonas aeruginosa andClostridium difficile were resistant to ALP-201. When tested against aerobic bacteria using a high inoculum or using the broth dilution technique, the activity of ALP-201 showed little dependence on inoculum size and the bactericidal activity was similar to the inhibitory activity. Further investigations are warranted with ALP-201, which is absorbed from the gastrointestinal tract after oral administration.

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References

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Authors and Affiliations

  1. Department of Clinical Microbiology, Karolinska Institute, Karolinska Hospital, S-10401, Stockholm, Sweden

    M. Rylander

  2. Department of Microbiology, Karolinska Institute, Huddinge University Hospital and National Bacteriological Laboratory, Stockholm, Sweden

    C. E. Nord

  3. Department of Infectious Diseases, University of Lund, Lund, Sweden

    S. R. Norrby

Authors
  1. M. Rylander
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  2. C. E. Nord
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  3. S. R. Norrby
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Rylander, M., Nord, C.E. & Norrby, S.R. Comparative in vitro activity of the new oral penem ALP-201 against aerobic and anaerobic bacteria. Eur. J. Clin. Microbiol. Infect. Dis. 8, 919–924 (1989). https://doi.org/10.1007/BF01963784

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  • DOI: https://doi.org/10.1007/BF01963784

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